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Facility

NINDS Intramural Research Support Facilities

The PROTEIN/PEPTIDE SEQUENCING FACILITY provides amino acid sequencing of purified proteins/peptides for NINDS investigators. The facility is also available for collaborations involving protein/peptide purification and more complicated sequencing strategies.

The FLOW CYTOMETRY CORE FACILITY provides intellectual, technical, training and collaborative support to NINDS and other intramural investigators in both basic and clinical research programs requiring seamless and productive use of conventional flow cytometry, imaging flow cytometry, preparative fluorescence-activated cell sorting (FACS) and in situ cytometric imaging techniques to assay cell biology at the molecular, subcellular and cellular levels, as specified by the investigator. Depending on the investigator's requirements, the Facility provides high-throughput screening of cells and assaying of their specific biological properties, in addition to preparative sorting of purified cell populations and/or subpopulations of interest, based on one of more specific cellular/subcellular parameters, as specified by the investigator. Facility staff is also continuously engaged in research and development of novel methodological approaches to comprehensively study systems biology in the brain using animal models for specific neurological and neurodegenerative disorders (ischemic and traumatic brain injuries, brain tumors, aging brain, select transgenic animal models of neurodevelopmental and neurodegenerative diseases, etc.), for which they combine up to 100-plex biomarker immunohistology screening with multi-spectral fluorescence imaging and multi-parametric big image data analyses.

The LIGHT IMAGING FACILITY provides intramural scientists with access to state-of-the-art light imaging equipment and expertise in light imaging techniques. The Facility offers training and assistance in a variety of light microscopic techniques including laser scanning confocal microscopy, video microscopy and digital image analysis. A digital image printer and slide maker are available for preparing illustrations for presentations and publications.

The EM FACILITY provides intramural NINDS investigators with the opportunity to use electron microscopic techniques in their research programs. The Facility provides assistance in all aspects of electron microscopy including project planning, specimen preparation and training.

The VIRAL PRODUCTION CORE FACILITY produces preclinical grade viruses for NIH investigators. The facility has produced Lentivirus, AAV virus and Rabies viral vectors. The Facility can provide the plasmid DNA cloning for viral vector production as well as viral packaging from plasmids produced outside of the facility. The Facility is also available for consultation and advice on the use of lenti and AAV viral vectors as well as production of novel viral vectors.

The TRANSLATIONAL NEUROSCIENCE CENTER The goal of this Center is to provide an infrastructure to assist researchers in preclinical and clinical studies to develop new diagnostics and treatments for neurological diseases.

The BIOINFORMATICS SECTION is located in Building 10 (5B06) and organized under the NINDS DIR IT program directed by Dr. Yang Fann. The Section consists of both Bioinformatics Scientist staff and Bioinformatics Programmer staff. The Section mission is to collaboratively assist NINDS research staff with BioInformatics-related projects as needed.