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Epilepsy

Program Duration: 2 years

FROM LEFT TO RIGHT: MEG spike source localization: dipole field map; MEG/EEG tracing; Magnetic source imaging



This is an integrated two-year fellowship in Clinical Epilepsy and neurophysiology for candidates with a demonstrated interest in academic neurology. The program is designed to foster the application of neurophysiology and Neuroimaging techniques to the evaluation and treatment of focal epilepsy and its co-morbidities. Fellows have exposure to the clinical inpatient and outpatient evaluation of patients with epilepsy with a focus on medically refractory focal epilepsy, including participation in our epilepsy monitoring unit, surgical evaluation and treatment, and longitudinal patient management through our outpatient clinics. Current areas of research interest are focused on structural and functional Neuroimaging to identify both normal and cognitive functions such as language and memory, as well as to better understand pathological changes related to epilepsy, as well as markers of inflammation related to epileptogenesis. Fellows benefit from the extensive research facilities and expertise available within the National Institutes of Health Intramural Research Program and the Clinical Center in Bethesda, MD. The program is affiliated with the Walter Reed National Military Medical Center and Children's National Medical Center, and both years are ACGME-certified, fulfilling the requirements for the American Board of Psychiatry and Neurology Added Qualification in Clinical Neurophysiology and Epilepsy. 

Area of Current Research

fMRI studies of language and memory in epilepsy
 Quantitative analysis of structural MRI for detection of subtle epileptogenic lesions
fMRI/EEG for seizures focus localization and seizure network evaluation
 MEG for seizure focus localization
Electrophysiological (ECoG and single unit activity) correlates of cognition and behavior
Decoding electrophysiological seizure markers and predictors

Faculty

William H. Theodore, M.D., Chief, Clinical Epilepsy Section, theodorw@ninds.nih.gov

William D. Gaillard, M.D., Child Neurologist, Clinical Epilepsy Section, gaillardw@ninds.nih.gov

Sara Inati, M.D., Chief, Electroencephalography Section, inatisk@mail.nih.gov

Kareem Zaghloul, M.D., Chief, Functional and Restorative Neurosurgery Unit, Surgical Neurology Branch, zaghloulka@mail.nih.gov