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Brain Imaging

Program Duration: 2–5 years

FROM LEFT TO RIGHT: High resolution 7T MRI based on T1 relaxation contrast, highlighting grey-white matter differences; High resolution 7T MRI sensitized to tissue magnetic properties, highlighting difference in iron and myelin content

The NINDS intramural program has a strong imaging program from basic molecular imaging to human studies. In addition to imaging for specific diseases there is an active MRI development program, as well as support for excellent facilities for both human and animal imaging. Active studies include technical developments in MRI to extend spatial resolution by developing very high-field MRI for humans and animal models as well as novel detectors. In addition there is interest in understanding important MRI contrast such as the significance of “resting state” fMRI fluctuations and the relation of functional MRI to neuronal architecture. Finally new contrast mechanisms such as phase contrast MRI, manganese enhanced MRI, and cell and molecular imaging techniques are being developed. These new MRI advances are rapidly translated to clinical studies of the structural anatomy, tissue metabolism, tissue perfusion, and blood oxygenation level-dependent (BOLD) contrast in both normal and diseased human brains. For clinicians interested in applications of imaging to research in neurological disorders, this fellowship offers an opportunity for combined training in advanced imaging techniques with a clinical focus. Clinical Fellows are encouraged to develop collaborative projects with a mentor from among the neuroimaging faculty and a relevant clinical investigator in a specific disease area. This offers the unique opportunity to translate new MRI techniques to a specific disease and to translate new information about neurological disorders to inspire new imaging techniques.

Areas of Current Research

For information regarding current research areas visit the Laboratory of Functional and Molecular Imaging website


Daniel Reich, M.D., Ph.D., Program Director, Translational Neuroradiology Unit,

Jeff Duyn, Ph.D., Chief, Advanced MRI Section,

Mary Kay Floeter, M.D., Ph.D., Chief, Motor Neuro Disorders Unit,

Alan Koretsky, Ph.D., Chief, Laboratory of Functional and Molecular Imaging (LFMI),

Larry Latour, Ph.D., Staff Scientist, Section on Stroke Diagnostics and Therapeutics,

Afonso Silva, Ph.D., Chief, Cerebral Microcirculation Section,