Worried About Dementia? You Might Want to Check Your Blood Pressure
NIH scientists watch the brain’s lining heal after a head injury
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
An MRI scan of a human brain highlighting the dural lymphatic system
Star-like cells may help the brain tune breathing rhythms
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Worried About Dementia? You Might Want to Check Your Blood Pressure

Dr. Walter Koroshetz was recently featured on National Public Radio (NPR) with a story on the link between high blood pressure and dementia. In 2016, at Dr. Koroshetz’s urging, OCPL designed and launched the Mind Your Risks® public education campaign to raise awareness about the importance of controlling blood pressure in midlife to help reduce the risk of having a stroke and possibly developing dementia later in life. Since its launch, Mind Your Risks has reached a wide audience with this important message.We are thrilled that Dr. Koroshetz had the opportunity to amplify NINDS research and education programs on NPR on Monday.    Learn More » Exit Disclaimer

NIH Scientists Watch the Brain’s Lining Heal After a Head Injury

Following head injury, the protective lining that surrounds the brain may get a little help from its friends: immune cells that spring into action to assist with repairs. In a new study led by Dr. Dorian McGavern, scientists from the National Institutes of Health watched in real-time as different immune cells took on carefully timed jobs to fix the damaged lining of the brain, also known as meninges, in mice. These results may help provide clues to the discovery that the meninges in humans may heal following mild traumatic brain injury (mTBI) and why additional hits to the head can be so devastating.    Learn More » Exit Disclaimer

Severing Enzymes Amplify Microtubule Arrays Through Lattice GTP-tubulin Incorporation

Dr. Antonina Roll-Mecak's laboratory recently published a paper in Science that shows active repair of microtubules by two enzymes involved in hereditary spastic paraplegias and microcephaly. This repair reinforces microtubules and allows microtubule arrays to rapidly amplify. The illustration  was featured in the front matter of the Science issue in which the publication appeared. Learn More » Exit Disclaimer

NIH Researchers Uncover Drain Pipes in Our Brains

Dr. Daniel Reich, a neuroradiologist and Senior Investigator at the NINDS, and his team used MRI to provide evidence of the body’s waste system in the human brain. By scanning the brains of healthy volunteers, researchers at the National Institutes of Health saw the first, long-sought evidence that our brains may drain some waste out through lymphatic vessels, the body’s sewer system. The results further suggest the vessels could act as a pipeline between the brain and the immune system. Learn More » Exit Disclaimer

Star-like Cells May Help the Brain Tune Breathing Rhythms

Traditionally, scientists thought that star-shaped brain cells called astrocytes were steady, quiet supporters of their talkative, wire-like neighbors, called neurons. Now, an NIH study led by Dr. Jeffrey Smith suggests that astrocytes may also have their say. It showed that silencing astrocytes in the brain’s breathing center caused rats to breathe at a lower rate and tire out on a treadmill earlier than normal. These were just two examples of changes in breathing caused by manipulating the way astrocytes communicate with neighboring cells.  Learn More » 

Isoform-specific cleavage of neuroligin-3 reduces synapse strength

Neuroligins are neuronal cell adhesion molecules that have been associated with autism spectrum disorders. However, recent reports have identified a cleaved form of Neuroligin-3 (NLGN3) as a potent mitogen, which promotes glioma growth. A publication of a new study led by Dr. Katherine Roche demonstrates that NLGN3 is proteolytically cleaved in response to synaptic activity and protein kinase C signaling resulting in reduced synapse strength. These findings show an unexpected neuronal role for neuroligins in synapse disassembly. In addition, these mechanistic insights into NLGN3 cleavage could aid in developing novel therapeutic targets for glioma.  Learn More »