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Investigator

Kevin L Briggman, Ph.D.

Circuit Dynamics and Connectivity Unit


Building 35A Room 3F147
35A Convent Dr
Bethesda MD 20892-
Office: (301) 402-7155


briggmankl@mail.nih.gov

Dr. Briggman received his B.S. in Electrical Engineering from Case Western Reserve University in 2000 and his Ph.D. in Computational Neurobiology from the University of California, San Diego in 2005, where he studied behavioral choice using voltage-sensitive dye population imaging in the leech nervous system with Bill Kristan. During a postdoctoral fellowship with Winfried Denk at the Max Planck Institute for Medical Research, he worked on the development of serial block-face scanning electron microscopy and used it in combination with two-photon population calcium imaging to investigate the circuit mechanisms underlying direction-selectivity in the mammalian retina. Dr. Briggman joined NINDS as an investigator in 2011. His laboratory develops large scale optical and electron microscopy-based methods to functionally and structurally map neuronal circuits in the central nervous systems of mice and fish.



Staff Image
  • Ms. Boma Fubara, B.S.
    Laboratory Manager

  • Kara Fulton, B.S.
    Brown-NIH GPP Student

  • Dr. Christopher Harris, Ph.D.
    Postdoctoral Fellow

  • Dr. Marta Pallotto, Ph.D.
    Postdoctoral Fellow

  • Matthew Schiel, M.S.
    Brown-NIH GPP Student

  • Dr. Paul Watkins, Ph.D.
    Software Engineer

  • Hailiang Zhang, Ph.D.
    Software Engineer

  • 1) Ding H,Smith RG,Poleg-Polsky A,Diamond JS,Briggman KL (2016)
  • Species-specific wiring for direction selectivity in the mammalian retina.
  • Nature, 535, 105-110
  • 2) Pallotto M, Watkins PV, Fubara B, Singer JH, Briggman KL (2015)
  • Extracellular space preservation aids the connectomic analysis of neural circuits.
  • Elife, 4
  • 3) Helmstaedter M, Briggman KL, Turaga SC, Jain V, Seung HS, Denk W (2013)
  • Connectomic reconstruction of the inner plexiform layer in the mouse retina
  • Nature, 500, 168-74
  • 4) Briggman KL, Bock DD (2012)
  • Volume electron microscopy for neuronal circuit reconstruction
  • Curr Opin Neurobiol, 22(1), 154-61
  • 5) Briggman KL, Helmstaedter M, Denk W (2011)
  • Wiring specificity in the direction-selectivity circuit of the retina
  • Nature, 471(7337), 183-8
  • 6) Helmstaedter M, Briggman KL, Denk W (2011)
  • High-accuracy neurite reconstruction for high-throughput neuroanatomy
  • Nat Neurosci., 14(8), 1081-8
  • 7) Briggman KL, Kristan WB Jr. (2006)
  • Imaging dedicated and multifunctional neural circuits generating distinct behaviors
  • J Neurosci, 26(42), 10925-33
  • 8) Briggman KL, Abarbanel HD, Kristan WB Jr. (2005)
  • Optical imaging of neuronal populations during decision-making
  • Science, 307(5711), 896-901
View Pubmed Publication