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Senior Scientist

Johan Pahlberg, Ph.D.

Synaptic Physiology Section/Photoreceptor Physiology Group

Porter Neuroscience Research Center
Building 35A Room 2F-233
MSC3701
Bethesda MD 20892-3701
Office: (301) 451-1307

Fax: (301) 480-5895
johan.pahlberg@nih.gov

Dr. Johan Pahlberg received his Ph.D. from the University of Helsinki, Finland, in 2007. His doctoral work, under the supervision of Professor Kristian Donner, focused on the adaptive evolution of visual pigments, and molecular mechanisms optimizing signaling in rod photoreceptors. His postdoctoral work with Dr. A.P. Sampath at the University of Southern California and University of California Los Angeles, focused on how mechanisms in rod bipolar cells is modulated for optimal signal detection in the retina. His current work is aimed at elucidating how rod photoresponses are processed and parsed into the retinal circuitry, and thus how optimization of response transmission already at the first visual synapse is achieved, by integrating physiology with genetics.



The photoreceptors of the retina have been studied extensively over the past decades. However, much of the downstream processing from photoreceptors remains to be determined. Textbooks and review articles will argue that the function of the retina is to simply convey the visual stimulus to the brain, where complex computations can take place. However, the neural circuitry of the retina has a marvelous complexity consisting of ~55-60 clearly distinct cell types. How these cells process the visual information from the photoreceptors is a fascinating enigma and answering these questions will reveal fundamental mechanisms and strategies used in neural processing and sensory signaling. Research on visual disorders such as Stationary Night Blindness, Retinal Degeneration and other impairments in low light level vision will benefit greatly from a general understanding of the rod photoreceptors and their retinal circuitry. The long-term goal is to have a substantial impact on vision rescue therapies and artificial vision. Research methods will include single cell patch-clamp recordings, whole retina electroretinogram recordings and behavioral experiments.

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  • Ulisse Bocchero, Ph.D.
    Postdoctoral Fellow

  • 1) Johan Pahlberg, Anurima Majumder, Nikolai O. Artemyev (2018)
  • Ex vivo functional evaluation of synaptic transmission from rods to rod bipolar cells in mice
  • In Methods in Molecular Biology, Mouse Retinal Phenotyping: Methods and Protocols , Vol. 1753: 203-216, (Tanimoto N, ed) Humana Press, New York, NY
  • 2) Tian Wang, Johan Pahlberg, Jon Cafaro, Alapakkam P Sampath, Greg D Field, Jeannie Chen (2018)
  • Activation of rod input in a model of retinal degeneration reverses retinal remodeling and induces formation of normal synapses, circuitry and visual signaling in the adult retina
  • bioRxiv 469221, doi: https://doi.org/10.1101/469221
  • 3) Johan Pahlberg*, Rikard Frederiksen*, Gabriel Pollock, Kiyoharu Miayagishima, Alapakkam P. Sampath, Carter Cornwall (2017)
  • Voltage-sensitive conductances increase the sensitivity of rod photoresponses following pigment bleaching
  • J Physiol , 595, 3459–3469
  • 4) Johan Pahlberg*, Anurima Majumder*, Hakim Muradov, Kimberly K. Boyd, Alapakkam P. Sapath, Nikolai O. Artemyev (2015)
  • Exchange of cone for rod phosphodiesterase 6 catalytic subunits in rod photoreceptors mimics in part features of light adaptation
  • Journal of Neuroscience , 35(24), 9225-35
  • 5) Johan Pahlberg*, Anurima Majumder*, Kimberly K. Boyd, Vasily Kerov, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Alapakkam P. Sampath, Nikolai O. Artemyev (2013)
  • Transducin translocation contributes to rod survival and enhance synaptic transmission from rods to rod bipolar cells
  • Proc Natl Acad Sci, 110(30), 12468-12473
  • 6) Johan Pahlberg*, Yan Cao*, Ignacio Sarria, Naomi Kamasawa, Alapakkam P. Sampath, Kirill A. Martemyanov (2012)
  • RGS7 and RGS11 provide the main GAP for the Gαo and set the sensitivity and time scale of rod ON bipolar light responses
  • Proc Natl Acad Sci , 09(20), 7905-10
  • 7) Johan Pahlberg, Alapakkam Sampath (2011)
  • The mitigation of transduction and synaptic noise in sensory systems is key to setting detection threshold
  • Bioessays, 33(6), 438-477
  • 8) Johan Pahlberg, Magnus Lindström, Petri Ala-Laurila, Nanna Fyhrquist-Vanni, Ari Koskelainen, Kristian Donner (2005)
  • The photoactivation energy of the visual pigment in two spectrally different populations of Mysis relicta (Crustacea, Mysida).
  • J. Comp. Physiol. A , 191(9), 837-844
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