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Senior Investigator

Alan P. Koretsky, Ph.D.

Laboratory of Functional and Molecular Imaging


Building 10 Room B1D728
10 Center Drive MSC 1065
Bethesda MD 20892-1065
Office: (301) 402-9659
Lab: (301) 402-9659
Fax: (301) 480-2558
koretskya@ninds.nih.gov

Dr. Koretsky received his B.S. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the NHLBI at NIH studying regulation of mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent twelve years on the faculty in the Department of Biological Sciences at Carnegie Mellon University where he was the Eberly Professor of Structural Biology and Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Koretsky's laboratory is interested in two main areas. They are actively developing novel imaging techniques to visualize brain function and study the regulation of cellular energy metabolism combining molecular genetics with non-invasive imaging tools.

The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.

The second major research area is cellular energetics. In particular, we are interested in the role of the enzyme creatine kinase and regulation of mitochondrial metabolism. This work relies on combining non-invasive imaging tools and molecular genetics in the mouse to study mitochondrial function in vivo. Current areas of interest are to determine the role of creatine kinase in cell growth and death. We are also interested in characterizing changes in the mitochondrial proteome during changes in mitochondrial metabolism using novel two-dimensional gel electrophoresis techniques.

Staff Image
  • Tatjana Atanasijevic, Ph.D.
    Research Fellow
    (301) 435-4362

  • Nadia Bouraoud
    Animal Biologist
    (301) 451-9938

  • Seungsoo Chung, M.D., Ph.D.
    Research Fellow
    (301) 451-7226

  • Alexia Daoust, Ph.D.
    Visiting Fellow
    (301)594-7314

  • Steve Dodd, Ph.D.
    Staff Scientist
    (301) 402-0389

  • Emily Petrus, Ph.D.
    IRTA Fellow
    (301) 451-9936

  • Nikorn Pothayee, Ph.D.
    Research Fellow
    (301) 402-9709

  • Galit Saar, Ph.D.
    Research Fellow
    (301) 451-9913

  • Kathryn Sharer
    Animal Biologist
    (301) 402-9652

  • 1) Yu, Y. He, M. Wang, H. Merkle, S. Dodd, A Silva, and A.P. Koretsky (2015)
  • Single Vessel fMRI X
  • Nature Methods submitted.
  • 2) C. Qian, Q. Duan, S. Dodd, A. P. Koretsky, J. Murphy-Boesch (2015)
  • Sensitivity enhancement of an inductively coupled local detector using HEMT-based current amplifier.
  • Magnetic Resonance in Medicine in press, doi: 10.1002/mrm.25850
  • 3) G. Saar, N. Cheng, L. Belluscio, and A.P. Koretsky (2015)
  • Laminar specific detection of APP induced neurodegeneration and recovery using MEMRI in an olfactory based Alzheimer’s disease mouse model
  • Neuroimage, 118, 183-192, doi: 10.1016/j.neuroimage.2015.05.045
  • 4) G. Zabow, S. Dodd, and A.P. Koretsky (2015)
  • Shape-changing magnetic assemblies as high-sensitivity NMR readable nanoprobes
  • Nature 520, 73-77 doi:10.1038/nature14294. Cover picture for this issue was about this article
  • 5) C. Du, N.D. Volkow, A.P. Koretsky, and Y. Pan (2014)
  • Low-frequency calcium oscillations accompany deoxyhemoglobin oscillations in rat somatosensory cortex
  • Proc. Natl. Acad. Sci, 111, E4677-E4686, doi:10.1073/pnas.1410800111
  • 6) C. Qian, X. Yu, N. Pothayee, S. Dodd, N. Bouraoud, R.A. Star, K.M. Bennett, and A. Koretsky (2014)
  • Live nephron imaging by MRI
  • Am. J. Physiol Renal Physiol, 307(10): F1162-1168, Doi: 10.1152/ajprenal.00326.2014.
  • 7) X. Yu and A.P. Koretsky (2014)
  • Interhemispheric plasticity protects the deafferented somatosensory cortex from functional takeover following nerve injury
  • Brain Connect 4, 709-717. Doi 10.1089/brain.2014.0259.Invited manuscript for special issue celebrating career of James Hyde. Koretsky personal reflections on James Hyde in Brain Connect. 4 (9), 631-635
  • 8) N. Pothayee, D.Y. Chen, M.A. Aronova, C. Qian, N. Bouraroud, S. Dodd, R.D. Leapman, and A.P. Koretsky (2014)
  • Self-organized Mn(II)-Block Copolymer Complexes and their use for In Vivo MR Imaging of Biological Processes
  • J. Mater. Chem. B, 2, 7055-7064, Doi:10.1039/c4tb00911h.
  • 9) K.C. Gao, G. Nair, I.C. Cortese, A. Koretsky, and D.S. Reich (2014)
  • Sub-millimeter imaging of brain-free water for rapid volume assessment in atrophic brains
  • Neuroimage, 100 370-378 doi 10.1016/j.neuroimage, 2014.06.014.
  • 10) N. Pothayee, N. Pothayee, N. Hu, R. Zhang, D.F. Kelly, A.P. Koretsky, J.S. Ruffle (2014)
  • Manganese Graft Ionomer Complexes (MnGICs) for Dual Imaging and Chemotherapy. J. Materials Chem B
  • J. Materials Chem B, 2, 1087-1099, doi 10.1039/c3tb21299h
  • 11) G. Zabow, S.J. Dodd, S.J. and A.P. Koretsky (2014)
  • Ellipsoidal microcavities: electromagnetic properties, fabrication and use as multispectral MRI agents
  • Small, 10, 1902-1907, Doi:10.1002/smll.201303045.
  • 12) T.L. Roth, D. Nayak, T. Atanasijevic, A.P. Koretsky, L.L. Latour, and D.B. McGavern (2014)
  • Transcranial amelioration of inflammation and cell death after brain injury
  • Nature, 505, 223-228, doi:10.1038/nature12808
  • 13) X. Yu, C. Qian, D Chen, S. Dodd, and A.P. Koretsky (2014)
  • Deciphering Laminar-Specific Neural Inputs with Line-Scanning fMRI
  • Nature Methods 11, 55-58. doi:10.1038/nmeth.2730.
  • 14) Y.Chen, A.M. Pasapera, A.P. Koretsky, and C.M. Waterman (2013)
  • Orientation-specific Response to Sustained Uniaxial Stretching in Focal Adhesion Growth and Turnover
  • Proc. Natl. Acad. Sci 110, E2352-E2361. Selected for Faculty of 1000Prime.
  • 15) Y. Chen, S.J. Dodd, M.A. Tangrea, M.R. Emmert-Buk, and A.P. Koretsky (2013)
  • Measuring Collective Cell Movement and Extracellular Matrix Interactions Using Magnetic Resonance Imaging
  • Sci. Rep, 3, 1879, doi: 10.1038/srep01879.
  • 16) N, Pothayee, S. Balasubramaniam, N. Pothayee, N. Jain, N. Hu, Y. Lin, R.M. Davis, N. Sriranganathan, A. P. Koretsky, and J.S. Riffle (2013)
  • Magnetic Nanoclusters with Hydrophilic Spacing for Dual Drug Delivery and Sensitive Magnetic Resonance Imaging
  • J. Materials Chem B, 1, 1142-1149
  • 17) C. Qian, X. Yu, D.Y. Chen, S. Dodd, N. Bouraroud, N. Pothayee, Y. Chen, S. Beeman, K. Bennett, J. Murphy-Boesch, and A. P. Koretsky (2013)
  • Wireless Amplified NMR Detector (WAND) for high resolution MRI of internal organs
  • Radiology, 268, 228-236
  • 18) S. Matsumoto, K. Saito, H. Yasui, H.D. Morris, J.P. Munasinghe, M. Lizak, H. Merkle, J.H. Ardenkjaer, R. Choudhuri, N. Devasahayam, S. Subramanian, A.P. Koretsky, J.B. Mitchell, and M.C. Krishna (2013)
  • EPR Oxygen Imaging and Hyperpolarized 13C MRI of Pyruvate Metabolism as Non-invasive Biomarkers of Tumor Treatment Response to a Glycolysis Inhibitor 3-bromopyruvate
  • Magn Resonan Med, 69, 1443-1450
  • 19) Q. Qian, G. Zabow, and A.P. Koretsky (2013)
  • Engineering Novel Detectors and Sensors for MRI
  • J. Magn Resonan, 229, 67-74
  • 20) C. Qian, J. Murphy-Boesch, S. Dodd, and A. P. Koretsky (2012)
  • Sensitivity Enhancement of Remotely Coupled NMR Detectors Using Wirelessly Powered Parametric Amplification
  • Magn Resonan Med, 68, 989-996
  • 21) A.P. Koretsky (2012)
  • Is there a path beyond BOLD? Molecular Imaging of Brain Function
  • Neuroimage 62, 1208-1215.. Invited article for special 20th Anniversary of fMRI issue of Neuroimage.
  • 22) A.P. Koretsky (2012)
  • Early Developments of Arterial Spin Labeling to Measure Regional Blood Flow by MRI
  • Neuroimage 62, 602-607. Invited article for special 20th Anniversary of fMRI issue of Neuroimage
  • 23) X. Yu*, S, Chung*, S. Wang, S.J. Dodd, J. Walters, J. Isaac#, and A.P. Koretsky# (2012)
  • Thalamocortical Inputs Show Post-Critical-Plasticity
  • Neuron 74, 731-742. authors contributed equally, #mentors contributed equally
  • 24) Y.C. Lee, D. Y. Chen, S. J. Dodd, N. Bouraoud, A.P. Koretsky, and K.M. Krishnan (2012)
  • The Use of Silica Coated MnO Nanoparticles to Control MRO Relaxivity in Response to Specific Physiological Changes
  • Biomaterials, 33, 3560-3567
  • 25) X. Yu, D. Glen, S. Wang, S. Dodd, Y. Hirano, Z. Saad, R. Reynold, A.C. Silva, and A.P. Koretsky (2012)
  • Direct Imaging of Macrovascular and Microvascular Contributions to BOLD fMRI in Layer IV-V of the Rat Barrel Cortex
  • Neuroimage, 59, 1451-1460
  • 26) R.S. Balaban and A.P. Koretsky (2011)
  • Interpretation of 31P NMR Saturation Transfer Experiments: What You Can’t See Might Hurt You
  • Am J. Physiol, 301, C12-C15
  • 27) J. H. Duyn and A.P. Koretsky (2011)
  • New Frontiers in MRI of the Brain
  • Current Opinions in Neurology, 24, 386-393
  • 28) A.G. Goloshevsky, C.W.H. Wu, S. J. Dodd, and A.P. Koretsky (2011)
  • Mapping Cortical Representations of the Rodent Forepaw and Hindpaw with BOLD fMRI Reveals Two Spatial Boundaries
  • Neuroimage, 57, 526-538
  • 29) C. W.-H. Wu, O. Vasalatily, H. Wu, N. Liu, D-Y Chen, A.P. Koretsky, G. Griffths, R.B.H. Tootell and L. G. Ungerleider (2011)
  • Development of a MR-Visible Compound for Tracing Neuroanatomical Connections In Vivo
  • Neuron, 70, 229-243
  • 30) H. Merkle, J. Murphy-Boesch, P. van Gelderen, S. Wang, T.Q. Li, A.P. Koretsky and J.H. Duyn (2011)
  • Transmitt B1 Correction at 7T using Actively Tuned Coupled Inner Elements
  • Magn Resonan Med, 66, 901-910
  • 31) M.I. Kettunen, M.K. Cherukuri, J.B, Michell, M.J. Lizak, H.D. Morris, S. Matsumoto, A.P. Koretsky, and K.M. Brindle (2011)
  • Detecting Response of Rat C6 Glioma Tumors to Radiotherapy using Hyperpolarized [1-(13)C]pyruvate and (13)C Magnetic Resonance Spectroscopic Imaging S.E. Day
  • Magn Resonan Med, 65, 557-563
  • 32) Y. Chen, S. Guzik, J.P. Sumner, J. Moreland, and A.P. Koretsky (2011)
  • Magnetic Manipulation of Actin Orientation, Polymerization and Gliding on Myosin using Superparamagnetc Iron Oxide Particles
  • Nanotechnology, 22, 65101
  • 33) G. Zabow, S. J. Dodd, E. Shapiro, J. Moreland, and A.P. Koretsky (2011)
  • Microfabricated High-Moment Micrometer Sized MRI Contrast Agents
  • Magn Resonan. Med, 65, 645-655
  • 34) T.C, Hu, K.H. Chuang, N. Yanasak, and A.P. Koretsky (2011)
  • Relationship Between Blood and Myocardial Manganese Levels During Manganese-Enhanced MRII (MERI) with T1 Mapping in Rats
  • NMR Biomed, 24, 46-53
  • 35) J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010)
  • Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation
  • Acta Neurolo Scand, 121, 209-216
  • 36) X. Yu, S. Wang, D-Y Chen, S. Dodd, A. Goloshevsky, and A.P. Koretsky (2010)
  • 3D Mapping of Somatotopic Reorganization with Small Animal Functional MRI
  • Neuroimage, 49, 1667-1676
  • 37) K-H Chuang, L. Belluscio, and A.P. Koretsky (2010)
  • In vivo Detection of Individual Glomeruli in the Rodent Olfactory Bulb Using Manganese Enhanced MRI
  • Neuroimage, 49, 1350-1356
  • 38) R.S. Conroy, A.P. Koretsky, and J. Moreland (2010)
  • Lambda Exonuclease Digestion of CGG Trinulcoetide Repeats
  • Eur. J. Biophys, 39, 337-343
  • 39) R.S. Conroy, A.P. Koretsky, and J. Moreland (2010)
  • Lambda Exonuclease Digestion of CGG Trinulcoetide Repeats
  • Eur. J. Biophys, 39, 337-343
  • 40) T.Q. Li, B. Yao, P. van Gelderen, H. Merkle, S. Dodd, L. Talagala, A.P. Koretsky, and J. Duyn (2009)
  • Characterization of T2* Heterogeniety in Human Brain White Matter
  • Magn Resonan Med, 2009, 1652-1657
  • 41) C. Du, M. Tully, N.D. Volkow, W.K. Schiffer, M. Yu, Z. Luo, A.P. Koretsky and H. Benveniste (2009)
  • Differential effects of Anesthetics on Cocaine’s Pharmacokinetic and Pharmacodynamic Effects in Brain
  • Eur. J. Neurosci, 30, 1565-1575
  • 42) G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2009)
  • The fabrication of uniform cylindrical magnetic nanoshells and their use as spectrally tunable MRI Contrast Agents
  • Nanotechnology, 20, 385301
  • 43) G. Pelled, D.A. Bergstrom, P.L. Tierney, R. Conroy, K.H. Chuang, D. Yu, D. Leopold, J.A. Walters and A.P. Koretsky, A.P (2009)
  • Ipsilateral Cortical fMRI Responses Following Peripheral Nerve Damage in Rats Reflects Interneuron Mediated Inhibition
  • Proc. Natl. Acad. Sci USA, 106, 14114-14119
  • 44) A. Androutsellis-Theotokis, M. Rueger, D. Park, H. Mkhikian, E. Korb, S. Poser, S. Walbridge, J. Munasinghe, A.P. Koretsky, R. Lonser, and R. McKay (2009)
  • Targeting Neural Precursors in the Adult Brain Rescues Injured Dopamine Neurons
  • Proc. Natl. Acad. Sci USA, 106, 13570-13575
  • 45) K.H. Chuang, A.P. Koretsky, and C.H. Sotak (2009)
  • Temporal Changes in the T1 and T2 Relaxation Rated (DR1 and DR2) in the Rat Brain are Consistent with the Tissue-Clearance Rates of Elemental Manganese
  • Magn Resonan Med, 61, 1528-1532
  • 46) J.J. Yin, K. tracy, J. Munasinghe, E. Shapiro, A.P. Koretsky and K. Kelley (2009)
  • Noninvasive Imaging of the Functional Effects of anti-VEGF Therapy on Tumor Cell Extravasation and Regional Blood Volume in an Experimental Brain Metastasis Model
  • Clinical and Experimental Metastasis, 26, 403-414
  • 47) G. Zabow, , A.P Koretsky, and J. Moreland (2009)
  • Design and fabrication of a Micromachined, Multi-Spectral Magnetic Resonance Imaging Agent
  • Journal of Micromechanics and Microengineering, 19, 025020+10.
  • 48) T.Q. Li, B. Yao, P. van Gelderen, H. Merkle, S. Dodd, L. Talagala, A.P. Koretsky, and J. Duyn (2009)
  • Characterization of T2* Heterogeniety in Human Brain White Matter
  • Magn Resonan Med, 2009, 1652-1657.
  • 49) C. Du, M. Tully, N.D. Volkow, W.K. Schiffer, M. Yu, Z. Luo, A.P. Koretsky and H. Benveniste (2009)
  • Differential effects of Anesthetics on Cocaine’s Pharmacokinetic and Pharmacodynamic Effects in Brain
  • Eur. J. Neurosci, 30, 1565-1575
  • 50) G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2009)
  • The fabrication of uniform cylindrical magnetic nanoshells and their use as spectrally tunable MRI Contrast Agents
  • Nanotechnology, 20, 385301
  • 51) G. Pelled, D.A. Bergstrom, P.L. Tierney, R. Conroy, K.H. Chuang, D. Yu, D. Leopold, J.A. Walters and A.P. Koretsky, A.P (2009)
  • Ipsilateral Cortical fMRI Responses Following Peripheral Nerve Damage in Rats Reflects Interneuron Mediated Inhibition
  • Proc. Natl. Acad. Sci USA, 106, 14114-14119.
  • 52) M. Rueger, D. Park, H. Mkhikian, E. Korb, S. Poser, S. Walbridge, J. Munasinghe, A.P. Koretsky, R. Lonser, and R. McKay (2009)
  • Targeting Neural Precursors in the Adult Brain Rescues Injured Dopamine Neurons. A. Androutsellis-Theotokis
  • Proc. Natl. Acad. Sci USA, 106, 13570-13575.
  • 53) K.H. Chuang, A.P. Koretsky, and C.H. Sotak (2009)
  • Temporal Changes in the T1 and T2 Relaxation Rated (DR1 and DR2) in the Rat Brain are Consistent with the Tissue-Clearance Rates of Elemental Manganese
  • Magn Resonan Med, 61, 1528-1532
  • 54) J.J. Yin, K. tracy, J. Munasinghe, E. Shapiro, A.P. Koretsky and K. Kelley (2009)
  • Noninvasive Imaging of the Functional Effects of anti-VEGF Therapy on Tumor Cell Extravasation and Regional Blood Volume in an Experimental Brain Metastasis Model.
  • Clinical and Experimental Metastasis, 26, 403-414.
  • 55) G. Zabow, , A.P Koretsky, and J. Moreland (2009)
  • Design and fabrication of a Micromachined, Multi-Spectral Magnetic Resonance Imaging Agent.
  • Journal of Micromechanics and Microengineering, 19, 025020+10
  • 56) K.H. Chuang and A.P. Koretsky (2009)
  • Accounting for Nonspecific Enhancement in Neuronal Tract Tracing Using Manganese Enhanced MRI
  • Magnetic Resonance Imaging, 27, 594-600
  • 57) S. Wang, J. Murphy-Boesch, H. Merkle, A.P. Koretsky, and J. Duyn (2009)
  • B1 Homogenization in MRI by Multilayered Coupled Coils.
  • IEEE Trans Med. Imaging, 28, 551-554
  • 58) K.H. Chuang, J.H. Lee, A.C. Silva, L. Belluscio, and A.P. Koretsky (2009)
  • Manganese Enhanced MRI Reveals Functional Circuitry in Response to Odorant Stimuli
  • Neuroimage, 44, 363-372
  • 59) J. Tucciarone, K-H Chuang, S.J. Dodd, A. Silva, G. Pelled, and A.P. Koretsky (2009)
  • Layer Specific Tracing of Corticocortical and Thalamocortical Connectivity in the Rodent Using Manganese Enhanced MRI.
  • Neuroimage, 44, 923-931
  • 60) J.P. Sumner, E.M. Shapiro, D. Maric, R. Conroy, and A.P. Koretsky (2009)
  • In vivo Labeling of Adult Neural Progenitors for MRI with Micron Sized Particles of Iron Oxide: Quantitation of Labeled Cell Phenotype
  • Neuroimage, 44, 671-678
  • 61) R.S. Conroy, G. Zabow, J. Moreland, and A.P. Koretsky (2008)
  • Controlled Transport of Magnetic Particles Using Soft Magnetic Patterns
  • Applied Physics Lett, 93, 203901-1-3
  • 62) K.M. Bennett, H. Zhou, J.P. Sumner, S.J. Dodd, N. Bouraoud, K. Doi, R.A. Star, and A.P. Koretsky (2008)
  • MRI of the basement membrane using charged nanoparticles as contrast agents
  • Magn Resonan Med, 60, 564-574
  • 63) G. Goelman, G. Pelled, S. Dodd, and A.P. Koretsky (2008)
  • Tracking the Effects of Crusher Gradients on Gradient-Echo Bold Signal in Space and Time During Rat Sensory Stimulation
  • Magn. Resonan. Med, 60, 548-554
  • 64) E.M. Shapiro and A.P. Koretsky (2008)
  • Convertible Manganese Contrast for Molecular and Cellular MRI
  • Magn Resonan Med, 60, 265-269
  • 65) J.M . Simmons, Z.S. Saad, M.J. Lizak, M. Ortiz, A.P. Koretsky and B. J. Richmond (2008)
  • Mapping Prefrontal Circuits in vivo with Manganese-Enhanced MRI in Monkeys
  • J. Neurosci, 28, 7637-7647
  • 66) J. H. Duyn and A.P. Koretsky (2008)
  • MRI of Neural Circuits
  • Nature Clinical Practice Cardiovascular Medicine (Invited contribution to supplement entitled "Cardiovascular Imaging for Clinicians") , 5, S71-78
  • 67) G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2008)
  • Micro-engineered Local Field Control for High-Sensitivity Multispectral MRI
  • Nature. Article was featured in Nature News and Views in commentary entitled, "A colourful future for MRI" by Richard Bowtell Nature 453, 993-994 (2008). Many media stories resulting from publication and NIST/NIH press release (eg stories by Reuters, Science News, Technology Review, etc...). Picked by editors of Nature as one of top articles of 2008 (Nature 456, xii-xiii, 2008), 453, 1058-1063
  • 68) F. Hyodo, K.H. Chuang, A.G. Goloshevsky, A. Sulima, G.L. Griffiths, J.B. Mitchell, A.P. Koretsky, M.C. Krishna (2008)
  • Brain Redox Imaging Using Blood-Brain Barrier Permeable Nitroxide MRI Contrast Agent
  • J. Cereb. Blood Flow Metab, 28, 1165-1174
  • 69) K-H Chuang, P. v. Gelderen, J. Bodurka, V.N. Ikonomidou, A. P. Koretsky, J. H. Duyn, S. L. Talagala (2008)
  • Mapping resting-state functional connectivity using perfusion MRI
  • Neuroimage, 40, 1595-1605
  • 70) K. M. Bennett, E. M. Shapiro, C. H. Sotak, and A. P. Koretsky (2008)
  • Controlled aggregation of ferritin to modulate MRI relaxivity
  • Biophysical J, 95, 342-351
  • 71) B. Stefanovic, E. Hutchinson, V. Yakovleva, V. Schram, J.T. Russell, L. Belluscio, A.P. Koretsky, and A.C. Silva (2008)
  • Functional Reactivity of Cerebral Capillaries
  • J. Cereb. Blood Flow Metab, 28, 961-972
  • 72) E.M. Shapiro and A.P. Koretsky in "Nanoparticles in Biomedical Imaging, Emerging Technologies and Applications" eds J. Bulte and M. Modo in "Fundamental Biomedical Technologies Vol3" ed M (2008)
  • Micron Sized Iron Oxide Particles (MPIOs) for Cellular Imaging: More Bang for the Buck
  • Ferrari, Springer, NY, pp 141-162
  • 73) A G. Goloshevsky, A. C. Silva, S. J. Dodd and A. P. Koretsky (2008)
  • The Dependence of BOLD fMRI and Somatosensory Evoked Potentials on Stimulation of the Rat Forepaw with Various Pulse Waveforms
  • Brain Res, 1195, 67-76
  • 74) A.C. Silva, J. H. Lee, C. W-H. Wu, I. Aoki, J. Tucciarone, G. Pelled, and A.P. Koretsky (2008)
  • Assignment of Cortical Laminar Architecture Using Manganese-Enhanced MRI
  • J. Neurosci Methods, 167, 246-257
  • 75) (2008)
  • Manganese cell Labeling of Murine Hepatocytes Using Manganese(III)-Transferrin. C. Sotak, K. Sharer, and A.P. Koretsky
  • Contast Med. Mol Imaging, 3, 95-105
  • 76) J. P. Sumner, R. Conroy, E.Shapiro, J. Moreland, and A.P. Koretsky (2007)
  • Delivery of Fluorescence Probes Using Iron Oxide Particles as Carriers Enables In Vivo Labeling of Migrating Neural Precursors for MRI and Optical Imaging
  • J Biomed Optics, 12, 5104-
  • 77) E.M. Shapiro, L.N. Medford-Davis, T.M. Fahmy, C.E. Dunbar, and A.P.Koretsky (2007)
  • Antibody-Mediated Cell Labeling of Peripheral T Cells with Micron Sized Particles of Iron Oxide (MPIOs) Allows Single Cell Detection by MRI.
  • Contrast Media Mol. Imaging, 2, 147-153
  • 78) J.H. Duyn, P. van Gelderen, T.Q. Li, J.A. deZwart, A. P. Koretsky, and M. Fukunaga (2007)
  • High-Field MRI of Brain Cortical Substructure Based on Signal Phase
  • Proc. Natl. Acad. Sci USA. Article was featured in "In this Issue" section of Proc. Natl. Acad. Sci USA and a commentary about this article was written by Wald and Fischl (2007) Proc. Natl. Acad. Sci. USA 104, 11513-11514. Work was ranked 53 of 100 top science stories of 2007 by Discover Magazine (Jan. 2008 issue p. 51) , 104, 11796-11801
  • 79) G. Pelled, K.H. Chuang, S.J. Dodd, and A.P. Koretsky (2007)
  • Functional MRI Detection of Bilateral Cortical reorganization in the Rodent Brain Following Complete Peripheral Nerve Dennervation
  • Neuroimage, 37, 262-273
  • 80) Silva, A.C., Koretsky, A.P., and Duyn, J.H (2007)
  • Functional MRI Impulse Response for BOLD and CBV Contrast in Rat Somatosensory Cortex
  • Magn Resonan Med, 57, 1110-1118
  • 81) G. Goelman, G. Pelled, G., S. Dodd, and A.P. Koretsky, A.P. (2007)
  • Observation of Two Distinct spatial-temporal BOLD clusters During Sensory Stimulation in Rats.
  • Neuroimage, 34, 1230-1226.
  • 82) C. Du, N.D. Volkow, A.P. Koretsky, J.S. Fowler, and H. Benveniste. (2006)
  • Cocaine Increases the Intracellular Calcium Concentration in Brain Independently of its Cerebrovascular Effects.
  • J. Neuroscience, 26, 11522-11531
  • 83) C.S. Landis, K. Yamanouchi, H. Zhou. S. Mohan, N. Roy-Chowdhury, D.A. Shafritz, A. P. Koretsky, J. Roy-Chowdhury, H. P. Hetherington, and C. Guha (2006)
  • Magnetic Resonance Spectroscopic Imaging Based Noninvasive Evaluation of Liver Repopulation by Transplanted Hepatocytes
  • Hepatology, 44, 1250-1258
  • 84) E.M. Shapiro, O. Gonzalez, J. M. Garcia-Verdugo, A. Alvarez-Buylla, and A.P. Koretsky (2006)
  • Magnetic Resonance Imaging of the Migration of New Neuronal Presursors Generated in the Adult Rodent Brain
  • Neuroimage, 32, 1150-1157
  • 85) Li, P. van Gelderen, H. Merkle, L. Talagala, A.P. Koretsky, and J. Duyn (2006)
  • Extensive Heterogeneity in White Matter Contrast in High Resolution T2*-weighted MRI of the Human Brain at 7.0T. T.Q.
  • Neuroimage, 32, 1032-1040.
  • 86) E.B. Hutchinson, A. P. Koretsky , and A.C . Silva (2006)
  • Spatial Flow-Volume Dissociation of the Cerebral Microcirculatory Response to Mild Hypercapnia
  • Neuroimage, 32, 520-530
  • 87) Ken-ichiro Matsumoto, Atsuko Matsumoto, Fuminori Hyodo, Alan P. Koretsky, Anastasia L. Sowers, James B. Mitchell, and Murali C. Krishna (2006)
  • High Resolution Mapping of Tumor Redox Status by Magnetic Resonance Imaging using Nitroxides as Redox-Sensitive Contrast Agents
  • Clinical Cancer Research, 12, 2455-2462
  • 88) Rodriquez. O., Fricke, S., Chien, C., Dettin, L., Van Meter, J., Shapiro, E., dai, H.N., Casimiro, M., Ileva, L., Dagata, J., Johnson, M., Koretsky, A., and Albanese, C (2006)
  • Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI
  • Cell Cycle, 5, 113-119
  • 89) K. H. Chuang and A. P. Koretsky (2006)
  • Improved Neuronal Tract Tracing using Manganese Enhanced MRI with Fast T1 Mapping
  • Magn Resonan Med, 55, 604-611
  • 90) I. Aoki, Y. Takahashi, K. H. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R. W. Childs, and A. P. Koresky (2006)
  • Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride
  • NMR Biomed, 19, 50-59
  • 91) S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, and A. P. Koresky (2006)
  • BOLD and CBV weighted Functional MR Imaging of Rat Somatosensory System
  • Magn Resonan Med, 55, 316-324
  • 92) E. M. Shapiro, K. Sharer, S. Skrtic, and A. P. Koretsky (Dr. Shapiro was a Young Investigator Award Finalist at the 2005 International Society of Magnetic Resonance in Medicine meeting for this work) (2006)
  • In Vivo Detection of Single Cells by MRI
  • Magn Resonan Med, 55, 242-249
  • 93) J.H. Duyn, P. van Gelderen, L. Talagala, A. P. Koretsky and J.A. de Zwart (2005)
  • Technological Advances in MRI Measurement of Brain Perfusion
  • J. Magn. Resonan. Imaging, 22, 751-753
  • 94) U. Himmelreich, R. Weber, P. Ramos-Cabrer, S. Wegener, K. Kandal, E. M. Shapiro, A.P. Koretsky, M. Hoehn (2005)
  • Improved Stem Cell MR Detectability in Animal Models by Modification of the Inhalation Gas
  • Molecular Imaging, 4, 104-109
  • 95) C. Du, A. P. Koretsky, I. Izrailtyan and H. Benveniste (2005)
  • Simultaneous Detection of Blood Volume, Oxygenation, and Intracellular Calcium Changes during Cerebral Ischemia and Reperfusion In Vivo using Photospectrometry.
  • J. Cerebral Blood Flow and Metabolism, 25, 1078-1092
  • 96) T.C. Hu, T.F. Christian, A.H. Aletras, J.L. Taylor, A. P. Koretsky, and A.A. Arai (2005)
  • Manganese Enhanced MRI of Normal and Ischemic Canine Heart
  • Magn Resonan Med, 54, 196-200
  • 97) J.H. Lee, A.C. Silva, H. Merkle, and A.P. Koretsky (2005)
  • Manganese Enhanced MRI (MEMRI) of Mouse Brain after Systemic Administration of MnCl2: Dose Dependence and Temporal Evolution of T1 Contrast
  • Magn Resonan Med, 53, 640-648
  • 98) E.K Shapiro, S. Skrtic, and A.P. Koretsky (2005)
  • Sizing it Up: Cellular MRI Using Micron Sized Particles
  • Magn Resonan Med, 53, 329-338
  • 99) J.A. de Zwart, A.C. Silva, P. Van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A.P. Koretsky, J.A. Frank; and J.H. Duyn (2005)
  • Temporal Dynamics of the BOLD fMRI Impulse Response.
  • Neuroimage, 24, 667-677
  • 100) O. Speer, N. Back, T. Buerklen, D. Brdiczka, A.P. Koretsky, T. Walliman and O. Eriksson (2005)
  • Octameric Mitochondrial Creatine Kinase Induces and Stabilizes Contact Sites Between the Inner and Outer Membranes.
  • Biochem J, 385, 445-450
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