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Epilepsy

Clinical Epilepsy Section (CES), NINDS
William Theodore, M.D., Chief


Functional and Restorative Neurosurgery Unit, Surgicial Neurology Branch (SNB), NINDS
Kareem Zaghloul, Ph.D., Chief


Electroencephalography (EEG) Section, NINDS
Sara Inati, M.D., Chief
E-mail: inatisk@ninds.nih.gov

The EEG Section engages in collaborative research to better understand the pathophysiology of epilepsy, as well as to advance the evaluation and treatment of patients with medically refractory epilepsy. In close collaboration with the Clinical Epilepsy Section and the Surgical Neurology Branch, this section seeks to use neurophysiologic and neuroimaging techniques to improve the ability to localize epileptic foci in preparation for possible surgical resection. The section uses EEG, including noninvasive and invasive long-term monitoring, electrocorticography, intracarotid sodium amobarbital procedure (WADA test), and magnetoencephalography (MEG). The section is planning a study using a combination of EEG, fMRI and MEG to assist in localizing epileptogenic foci, describe abnormal networks of activity, and possibly compare results in terms of the evaluation of language and other cognitive functions.
 
The EEG Section provides support to intramural NIH investigators from all institutes and centers, both through the techniques mentioned above, as well as evoked potentials, intra-operative evoked responses and polysomnography.  

Faculty Information: Dr. Sara Inati is the Chief of the EEG Section of the Office of the Clinical Director, NINDS. She completed her undergraduate studies at Harvard College, and went on to receive her M.D. with honors from Dartmouth Medical School in 2003. She subsequently completed her medical internship at Lenox Hill Hospital, and her residency training in neurology at the Neurological Institute at Columbia University Medical Center. She continued on for two years of fellowship training in epilepsy and clinical neurophysiology at the Columbia Comprehensive Epilepsy Center. In 2010, she joined the NIH as Staff Clinician with the neurology consult service then joined the EEG Section the following year. She is board certified in Neurology. Dr. Susumu Sato (retired) serves as an additional faculty member in the EEG Section, having previously served as Chief from 1983-2011.


Epilepsy Studies Actively Recruiting Patients:
01-N-0139: Evaluation and Treatment of Patients With Epilepsy
07-N-0103: The Role of Serotonin in Seizures
11-N-0039: PRX-00023 Therapy in Localization-Related Epilepsy
12-N-0033: Buspirone Therapy for Localized Epilepsy
12-N-0182: Brain P-gp and Inflammation in People With Epilepsy
13-N-0127: Exercise Education for Adults With Seizure Disorders
14-N-0061: Noninvasive presurgical evaluation of patients with focal epilepsy
11-N-0051: Surgery As A Treatment for Medically Intractable Epilepsy