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Neurogenetics

 Program Duration: 2–5 years

Neurogenetics1
Neurogenetics2
FROM LEFT TO RIGHT: Rescue of neuromuscular junctions in spinal muscular atrophy model; IGF-1 mitigates Kennedy’s disease model



The mission of the Neurogenetics Branch is to reduce the burden of disease in patients with hereditary neurological disease. Fellows have the opportunity to study basic disease mechanisms using different model systems. These include various techniques in genomics, generation of inducible pleuripotent stem cells and animal models. The Fellows also have the opportunity to participate in conducting and designing therapeutic clinical trials using pharmacological and biological approaches. The Branch follows a number of cohorts of patients with genetic illnesses. A genetic outreach program is in place to identify and characterize patients, families, and children with both new and previously known hereditary neurological diseases.


Areas of Current Research

Huntington’s disease
Kennedy’s disease
Spinocerebellar ataxia
Spinal muscular atrophy
Hereditary motor neuron disease
Early onset muscle disorders
Charcot-Marie-Tooth neuropathies
Hereditary spastic paraplegias
Friedreich’s ataxia
Muscular dystrophies (Duchenne and LGMD)
Congenital muscular dystrophies and myopathies

Faculty

Kenneth Fischbeck, M.D., Chief, Neurogenetics Branch, kf@ninds.nih.gov

Craig Blackstone, M.D., Ph.D., Chief, Cell Biology Section, blackstc@ninds.nih.gov

Carsten Bönnemann, M.D., Chief, Neuromuscular and Neurogenetic Disorders of Childhood Section, carsten.bonnemann@nih.gov

Ami Mankodi, M.D., Investigator, Hereditary Muscle Diseases Unit, Neurogenetics Branch, ami.mankodi@nih.gov

Sonja Scholz, M.D., Assistant Clinical Investigator, Neurogenetics Branch, sonja.scholz@nih.gov

Michael Ward, M.D., Assistant Clinical Investigator, Neurogenetics Branch, michael.ward4@nih.gov

Mary Kay Floeter, M.D., Ph.D., Chief, Motor Neuron Diseases Unit, floeterm@ninds.nih.gov


Bryan Traynor, M.D., Ph.D., Neuromuscular Diseases Research Unit, Laboratory of Genetics, NIA, traynorb@mail.nih.gov