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Kareem Zaghloul

Kareem Zaghloul, MD, PhD


Tenure-Track Investigator

M.D., University of Pennsylvania

Ph.D., University of Pennsylvania

Clinical interests: functional neurosurgery, brain tumors, epilepsy, deep brain stimulation, spinal tumors

Research interests: cortical functional networks, neural mechanisms of cognitive function, brain machine interfaces, human neurophysiology






















Dr. Zaghloul attended the Massachusetts Institute of Technology (MIT) where he received a Bachelor’s of Science in Electrical Engineering and Computer Science. He then obtained his MD and PhD in Neuroscience from the University of Pennsylvania. His PhD graduate school work focused on developing silicon models of visual processing in the mammalian retina with Dr. Kwabena Boahen. Dr. Zaghloul subsequently completed a residency in Neurological Surgery at the University of Pennsylvania under Dr. M. Sean Grady. During his residency, he completed postdoctoral research with Dr. Michael Kahana, investigating the neural correlates of human memory encoding, decision, and reward. Dr. Zaghloul has completed clinical fellowships in Epilepsy Surgery with Dr. Johannes Schramm and in DBS Surgery with Dr. Gordon Baltuch. Dr. Zaghloul joined NINDS as a Staff Clinician in 2010, and as a Tenure-Track Investigator in 2013.

Dr. Kareem A. Zaghloul, MD, PhD is a board-certified neurosurgeon with clinical expertise and research efforts related to epilepsy surgery, brain tumors, and movement disorders. Dr. Zaghloul’s clinical practice is focused on patients with medically refractory epilepsy, on patients with tumors of the brain and spine, and on patients requiring deep brain stimulation surgery. He has extensive experience with cortical and subcortical mapping in order maximize the removal of brain tumors and areas of seizure activity while preserving critical structures for language and movement.

As an Investigator in NINDS, Dr. Zaghloul ties his clinical practice to his research efforts focused on understanding the electrical signals captured from the brain. He routinely treats patients with epilepsy and brain tumors such as gliomas, metastatic tumors, and hemangioblastomas. Some of these patients require extensive mapping with temporary electrodes placed directly on the brain. Dr. Zaghloul and his team use these electrodes to understand how the brain processes information both in the healthy and diseased state, and to develop an optimal surgical strategy for each patient that will maximize the benefits of surgery.

    Education & Training:

  • Fellowship, University of Bonn, Bonn, Germany, Epilepsy Surgery, 2010
  • Chief Resident, University of Pennsylvania, Neurosurgery, 2009 – 2010
  • Fellowship, University of Pennsylvania, Psychology, 2007 – 2010
  • Fellowship, University of Pennsylvania, Stereotactic and Functional Neurosurgery, 2007 -2008
  • Residency, University of Pennsylvania, Neurosurgery, 2004 – 2009
  • Internship, University of Pennsylvania, General Surgery, 2003 – 2004
  • M.D., University of Pennsylvania, Medicine, 2003
  • Ph.D., MSc, University of Pennsylvania, Neuroscience, 2001
  • BSc, Massachusetts Institute of Technology, Electrical Engineering and Computer Science, 1995

    Clinical Interests:

  • Epilepsy
  • Brain Tumors
  • Parkinson’s Disease
  • Spine Tumors

    Organization and Professional Memberships:

  • 1994-Current Member, Institute of Electrical and Electronics Engineers
  • 1994-Current Member, Sigma Xi Research Society
  • 1995-Current Member, American Medical Association
  • 1998-Current Member, Society for Neuroscience
  • 2003-Current Member, American Association of Neurological Surgeons
  • 2003-Current Member, Congress of Neurological Surgeons

    Honors & Awards:

  • NIH K99/R00 Pathway to Independence Award
  • NIH Graduate Partnership Program Outstanding Mentor Award

    Selected Publications:

  • Zavala B, Damera S, Lungu C, Brown P, Zaghloul KA (2015) Human subthalamic nucleus theta and beta oscillations entrain neuronal firing during sensorimotor conflict Cerebral Cortex In Press
  • Yaffe RB, Kerr SD, Damera S, Sarma S, Inati SK, Zaghloul KA (2015) Reinstatement of distributed patterns of oscillatory power occurs with precise spatiotemporal dynamics during successful memory recall PNAS 111(52): 18727-18732
  • Haque RU, Wittig JH, Damera S, Inati SK, Zaghloul KA (2015) Cortical low frequency power and progressive phase synchrony precede successful memory encoding Journal of Neuroscience 35(40): 13577-13586
  • Yang AI, Vanegas N, Lungu Z, Zaghloul KA (2014) Beta coupled high frequency activity and beta locked neuronal spiking in the human subthalamic nucleus Journal of Neuroscience 34(38): 12816-12827
  • Zaghloul KA, Blanco JA, McGill K, Jaggi JL, Baltuch GH, Kahana MJ (2009) Human Substantia Nigra Neurons Encode Unexpected Financial Rewards Science 323: 1496-99

For additional publications, please click here.