Lucy Forrest - Prototype 01

Forrest Lab

National Institute of Neurological Disorders & Stroke


Forrest Lab Website

The Forrest lab, led by NIH Investigator Dr. Lucy R. Forrest, uses computational approaches to study proteins that exist in cell membranes. We are particularly interested in understanding the function of coupled transporter proteins through an understanding of their structure. We also develop methods to better enable the prediction of functionally important properties of such proteins. See our "Software & Data" link for more details.

The group was set up in the Max Planck Institute for Biophysics in Frankfurt, Germany, in 2007, and moved to the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH) in Bethesda, MD, USA in 2013. Currently the lab comprises 4 postdocs, and a post-baccalaureate fellow. Follow our "Lab Members" link for more details.

Useful Links:

  • Forrest group profile at NINDS - with information about Research Interests
  • The Faraldo Lab (faraldolab.org) - Our colleagues in the Theoretical Molecular Biophysics Section of NHLBI.

Lab News

New team member! 

We welcome Suhwan (Paul) Lee, a new postbaccalaureate student from Ole Miss!

New insights into coupling during symport

A recent collaboration with Gary Rudnick has just been accepted for publication. We identify a key molecular interaction responsible for responding to bound ligands and required for the major transport-related conformational change. See it in the bioRxiv here.

Neurotransmitter sequestration reviewed

A review of our structure-function studies with the Schulinder lab has just been published in the Journal of General Physiology. Learn how molecular modeling has driven biochemical studies to identify key regions of the vesicular monoamine transporter, VMAT2.

 

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