Since its founding in 2017, the CCB has financially supported a variety of research investigations. While some of these projects are only just beginning, others, listed below, have been submitted to and published by neuroscience academic journals. Please note that future papers will be added to this list as they are published.
Volitional social interaction prevents drug addiction in rat models.
Published by CCB Fellow Marco Venniro in Nature Neuroscience (October 2018)
Abstract: Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration. This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the addiction score. Social-choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCδ-expressing inhibitory neurons and inhibition of anterior insular cortex activity. These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments.
Novel models of drug relapse and craving after voluntary abstinence.
Published by CCB Fellow Marco Venniro in Neuropsychopharmacology (September 2018)
Abstract: Researchers introduced two novel models of choice-based voluntary abstinence and demonstrated the profound protective effects of positive social interaction on drug addiction and relapse in rat models. Findings support wider implementation of social-based behavioral treatments, which include not only the established community reinforcement approach, but also social-based psychotherapies and family-based social support systems to provide social support before and during drug-seeking episodes.
If research you completed with the help of CCB funding is in the process of being submitted for publication, please include the following affiliation and acknowledgement statements in your paper:
Center on Compulsive Behaviors, Intramural Research Program, NIH, Bethesda, MD, USA
This study was funded by the Center on Compulsive Behaviors, NIH via NIH Director’s Challenge Award to (YOUR INITIALS HERE)