Compulsive behaviors are repeated, perseverative actions that are difficult to inhibit despite clear intentions and harmful consequences for the patients. While their expression is diverse – ticks, compulsive eating, and addiction are all examples — compulsive behaviors are driven by shared neuro-circuitry that must be studied from the genetic and molecular level to system-based and behavioral expression. The CCB’s mission is to understand the neurobiology of complex behaviors that result in these compulsive and repetitive actions, and to develop and test new therapeutics aimed at alleviating or reversing these behaviors. By understanding the processes that promote or inhibit the development of compulsive behaviors, we can not only optimize existing treatments, but also for design new pharmacological and behavioral interventions.
The CCB is striving to advance scientific discovery in the field of compulsive behaviors and to develop expertise on the topic within the NIH Intramural Research Program (IRP). By bringing together basic scientists and clinical researchers from seven different Institutes, the Center fosters collaboration within the IRP neuroscience community, provides unique opportunities for research crossover and networking, and trains future experts in the field of compulsive behaviors.
The CCB was launched in 2017 with funding from the 2017 DDIR Innovation Award, and continued to be funded through the 2018 DDIR Challenge Innovation Award Program. Recently a longer term funding mechanism has been established with the help of 7 Institutes to enable the focus on collaborative research projects.
The recent funding commitment of NICHD, NIDA, NIDDK, NIEHS, NINDS, NIMH, and NIAAA, allows for the new call for fellowship applications in 2019. The current application round closed on April 15th, 2019.
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