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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIEHS

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Investigator

Steven S. Vogel, Ph.D.

Laboratory of Molecular Physiology
Room TS-06F
5625 Fishers Lane MSC9411
Rockville MD 20892-
Office: (301) 496-9288
Lab: (301) 496-9288

stevevog@mail.nih.gov

Dr. Vogel received his B.S. from the City College of New York in 1978 and his Ph.D. from Columbia University in 1989, where he studied G-proteins in the nervous systems of Aplysia and squid with Jimmy Schwartz. During a postdoctoral fellowship with Josh Zimmerberg at NIDDK and NICHD, he investigated the calcium dependence of exocytosis in sea urchin eggs and discovered heterogeneity for calcium responses in a population of secretory vesicles. Dr. Vogel next became an assistant and subsequently a tenured associate professor at the Medical College of Georgia (1997-2003), where he studied the mechanism of exocytosis - endocytosis coupling. He joined NIAAA as an investigator in 2003, and became a senior investigator in 2013. His laboratory develops new fiber optic and microscope-based assays using FRET, fluorescence polarization, and fluorescence correlation spectroscopy to study protein-protein interactions in living cells, focusing on the structure and function of CaMKII holoenzyme.



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  • 1) G. Cui, S. Jun, X. Jin, M.D. Pham, S.S. Vogel, D.M. Lovinger, and R.M. Costa (2013)
  • Concurrent activation of striatal direct and indirect pathways during action initiation
  • Nature, 494, 238-242
  • 2) T.A. Nguyen, P. Sarkar, J.V. Veetil, S.V. Koushik, and S.S. Vogel (2012)
  • Fluorescence polarization and fluctuation analysis monitor subunit proximity, stoichiometry, and protein complex hydrodynamics
  • PLoS One, 7, e38209
  • 3) J. F. Covian-Nares, S.V. Koushik, H.L. Puhl III, and S.S. Vogel (2010)
  • Membrane wounding triggers ATP release and dysferlin-mediated intercellular calcium signaling
  • J Cell Science , 123, 1884-1893
  • 4) S.S. Vogel (2009)
  • Channeling Calcium: A shared mechanism for exocytosis-endocytosis coupling
  • Science Signaling , 2, pe80
  • 5) C. Thaler, S.V. Koushik, H.L. Puhl III, P.S. Blank, and S.S. Vogel (2009)
  • Structural rearrangement of CaMKII-alpha catalytic domains encodes activation
  • Proc Natl Acad Sci U S A, 106, 6369-6374
  • 6) S. V. Koushik, H. Chen, C. Thaler, H.L. Puhl III, and S.S. Vogel (2006)
  • Cerulean, Venus and VenusY67C FRET reference standards
  • Biophysical Journal, 91, L99-101
  • 7) S S. Vogel, C. Thaler, and S.V. Koushik (2006)
  • Fanciful FRET
  • Science STKE, ,re2
  • 8) C. Thaler, S.V. Koushik, P.S. Blank, and S.S. Vogel (2003)
  • Quantitative Multiphoton Spectral Imaging and its use for Measuring Resonance Energy Transfer
  • Biophysical Journal , 89, 168-72
  • 9) R. M. Smith, B. Baibakov, Y. Ikebuchi, B. H. White, N. A. Lambert, L. K. Kaczmarek, and S. S. Vogel (2000)
  • Exocytotic Insertion of Calcium Channels Constrains Compensatory Endocytosis to Sites of Exocytosis
  • The Journal of Cell Biology, 148, 755-767
  • 10) S.S. Vogel, R. M. Smith, B. Baibakov, Y. Ikebuchi, and N. A. Lambert (1999)
  • Calcium influx is required for endocytotic membrane retrieval
  • Proc. Natl. Acad. Sci., USA, 96, 5019-5024
  • 11) S. S. Vogel, P. S. Blank, & J. Zimmerberg (1996)
  • Poisson distributed active fusion complexes underlie the control of the rate and extent of exocytosis by calcium
  • The Journal of Cell Biology, 134, 329-338
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