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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Senior Investigator

Okihide Hikosaka, M.D.

Section of Neuronal Networks
Building 49 Room 2A50
49 Convent Drive MSC 4435
Bethesda MD 20892-2235
Office: (301) 402-7959
Lab: (301) 496-9375
Fax: (301) 402-0511
oh@lsr.nei.nih.gov

Dr. Hikosaka received his M.D. and Ph.D. from University of Tokyo where he worked in the laboratory of Hiroshi Shimazu on the brainstem vestibulo-oculomotor system. He did postdoctoral research with Robert Wurtz at the Laboratory of Sensorimotor Research, NEI on the role of the substantia nigra pars reticulata in the control of saccadic eye movements. He became Assistant Professor at Toho University School of Medicine (Tokyo) in 1979, Full Professor at National Institute of Physiological Sciences (Okazaki) in 1988, and Full Professor at Juntendo University School of Medicine (Tokyo) in 1993. In 2002, he returned to the Laboratory of Sensorimotor Research, NEI as a Senior Investigator and Chief of the Section of Neuronal Networks. He was elected to the American Academy of Arts & Sciences in 2011. His main interest is the neural mechanisms of voluntary behavior. His laboratory studies the mechanisms of motivation, learning, skill, decision-making, attention, and oculomotor control.



Staff Image
  • Ethan Bromberg-Martin, Ph.D.
    Postdoctoral Fellow

  • Ali Ehsaei, Ph.D.
    Postdoctoral Fellow

  • Hyoung Kim, Ph.D.
    Postdoctoral Fellow

  • Ilya Monosov, Ph.D.
    Postdoctoral Fellow

  • Masaharu Yasuda, Ph.D.
    Postdoctoral Fellow

  • 1) Daye PM, Monosov IE, Hikosaka O, Leopold DA, Optican LM (2013)
  • pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping.
  • J Neurosci Methods, 213(1), 123-31
  • 2) Monosov IE, Hikosaka O (2013)
  • Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region.
  • Nat Neurosci , 16(6), 756-62
  • 3) Yamamoto S, Kim HF, Hikosaka O (2013)
  • Reward value-contingent changes of visual responses in the primate caudate tail associated with a visuomotor skill.
  • J. Neurosci, 33(27), 11227-38
  • 4) Kim HF, Hikosaka O (2013)
  • Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values.
  • Neuron, 79(5), 1001-10
  • 5) Hong S, Hikosaka O (2013)
  • Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey.
  • Front Hum Neurosci, 7, 778
  • 6) Hikosaka O, Yamamoto S, Yasuda M, Kim HF (2013)
  • Why skill matters.
  • Trends Cogn Sci, 17(9), 434-41
  • 7) Hikosaka O, Isoda M (2010)
  • Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms.
  • Trends Cogn Sci., 14(4), 154-61
  • 8) Yugeta A, Terao Y, Fukuda H, Hikosaka O, Yokochi F, Okiyama R, Taniguchi M, Takahashi H, Hamada I, Hanajima R, Ugawa Y (2010)
  • Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease.
  • Neurology, 74, 743-748
  • 9) Bromberg-Martin ES, Hikosaka O, Nakamura K (2010)
  • Coding of task reward value in the dorsal raphe nucleus.
  • J Neurosci, 30, 6262-72
  • 10) Hikosaka O. (2010)
  • The habenula: from stress evasion to value-based decision-making.
  • Nat Rev Neurosci., 11(7), 503-12
  • 11) Bromberg-Martin ES, Matsumoto M, Hikosaka O. (2010)
  • Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons.
  • Neuron, 15;67(1), 144-55
  • 12) Bromberg-Martin ES, Matsumoto M, Nakahara H, Hikosaka O. (2010)
  • Multiple timescales of memory in lateral habenula and dopamine neurons.
  • Neuron, 12;67(3), 499-510
  • 13) Bromberg-Martin ES, Matsumoto M, Hong S, Hikosaka O. (2010)
  • A pallidus-habenula-dopamine pathway signals inferred stimulus values.
  • J Neurophysiol, 104(2), 1068-76
  • 14) Bromberg-Martin ES, Hikosaka O (2009)
  • Midbrain dopamine neurons signal preference for advance information about upcoming rewards.
  • Neuron, 63, 119-126
  • 15) Matsumoto M, Hikosaka O (2009)
  • Two types of dopamine neuron distinctly convey positive and negative motivational signals.
  • Nature, 459, 837-841
  • 16) Hikosaka O. (2008)
  • Decision-making and learning by cortico-basal ganglia network.
  • Brain Nerve, Jul;60(7), 799-813
  • 17) Matsumoto M, Hikosaka O. (2008)
  • Negative motivational control of saccadic eye movement by the lateral habenula.
  • Prog Brain Res., 171, 399-402
  • 18) Matsumoto M, Hikosaka O (2008)
  • Representation of negative motivational value in the primate lateral habenula.
  • Nature Neurosci, 12, 77-84
  • 19) Matsumoto M, Hikosaka O. (2008)
  • Representation of negative motivational value in the primate lateral habenula.
  • Nature Neurosci, 12, epub
  • 20) Bissmarck F, Nakahara H, Doya K, Hikosaka O. (2008)
  • Combining modalities with different latencies for optimal motor control.
  • J Cogn Neurosci., Nov;20(11), 1966-79.
  • 21) Isoda M, Hikosaka O. (2008)
  • A neural correlate of motivational conflict in the superior colliculus of the macaque.
  • J. Neurophysiol., Sep;100(3), 1332-42
  • 22) Hikosaka O, Sesack SR, Lecourtier L, Shapard PD. (2008)
  • Habenula: crossroad between the basal ganglia and the limbic system.
  • J Neurosci., Nov 12:28(46), 11825-9
  • 23) Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M. (2008)
  • New insights on the subcortical representation of reward.
  • Curr Opin Neurobiol. , Apr:18(2), 203-8
  • 24) Nakamura K, Matsumoto M, Hikosaka O. (2008)
  • Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus.
  • J. Neurosci., May 14;28(20), 5331-43
  • 25) Isoda M, Hikosaka O. (2008)
  • Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement.
  • J Neurosci., Jul 9;28(28), 7209-18
  • 26) Hikosaka O, Isoda M. (2008)
  • Brain mechanisms for switching from automatic to controlled eye movements.
  • Prog Brain Res., 171, 375-82
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