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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Investigator

Mike Michaelides, Ph.D.

Biobehavioral Imaging & Molecular Neuropsychopharmacology Unit

Triad Technology Center
Room 3444
333 Cassell Drive
Baltimore MD 21224
Office: 443-740-2894
Lab: 443-740-2894
Fax: 443-740-2111
mike.michaelides@nih.gov

Mike Michaelides, Ph.D., Chief, Biobehavioral Imaging & Molecular Neuropsychopharmacology Unit, NIDA.

Post-doctoral Training: Icahn School of Medicine at Mount Sinai, New York, NY; Advisors: Yasmin L. Hurd, Ph.D. (primary), Gene Jack Wang, M.D. (secondary).

Ph.D.: Integrative Neuroscience (Biopsychology), Stony Brook University, Stony Brook, NY



Dr. Michaelides’ laboratory implements state-of-the-art biobehavioral molecular imaging approaches integrated alongside cutting-edge neuromodulatory, molecular, pharmacological, transgenic, and bioinformatic methods for identifying behaviorally-relevant neurobiological mechanisms critical for substance abuse and addiction. Special emphasis is placed on reverse-translating findings from clinical research to animals. In addition, clinical relevance of mechanisms studied in animals is determined in humans via imaging, bioinformatics, genetics and postmortem tissue examinations.

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  • 1) Thanos PK, Michaelides M, Subrize M, Miller ML, Bellezza R, Cooney RN, Leggio L, Wang GJ, Rogers AM, Volkow ND, Hajnal A (2015)
  • Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception
  • PLoS One, 2015 Jun 3;10(6):e0125570. doi: 10.1371/journal.po
  • 2) Michaelides M, Hurd YL (2015)
  • DREAMM: a biobehavioral imaging methodology for dynamic in vivo whole-brain mapping of cell type-specific functional networks
  • Neuropsychopharmacology, 2015 Jan;40(1):239-40, doi: 10.1038/npp.2014.233. Review
  • 3) Michaelides M, Miller ML, Subrize M, Kim R, Robison L, Hurd YL, Wang GJ, Volkow ND, Thanos PK (2013)
  • Limbic activation to novel versus familiar food cues predicts food preference and alcohol intake
  • Brain Res, 2013 May 28;1512:37-44. doi: 10.1016/j.brainres.20
  • 4) Anderson SA, Michaelides M, Zarnegar P, Ren Y, Fagergren P, Thanos PK, Wang GJ, Bannon M, Neumaier JF, Keller E, Volkow ND, Hurd YL. (2013)
  • Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression
  • J Clin Invest, 2013 Dec;123(12):5334-41. doi: 10.1172/JCI70395. E
  • 5) Michaelides M, Anderson SA, Ananth M, Smirnov D, Thanos PK, Neumaier JF, Wang GJ, Volkow ND, Hurd YL (2013)
  • Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks
  • J Clin Invest, 2013 Dec;123(12):5342-50. doi: 10.1172/JCI72117. E
  • 6) Michaelides M, Thanos PK, Kim R, Cho J, Ananth M, Wang GJ, Volkow ND (2012)
  • PET imaging predicts future body weight and cocaine preference
  • Neuroimage, 2012 Jan 16;59(2):1508-13. doi: 10.1016/j.neuroima
  • 7) Michaelides M, Pascau J, Gispert JD, Delis F, Grandy DK, Wang GJ, Desco M, Rubinstein M, Volkow ND, Thanos PK (2010)
  • Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate
  • Eur J Neurosci, 2010 Aug;32(4):668-76. doi: 10.1111/j.1460-9568.20
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