Skip to main content
NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

Profile Image

Investigator

Michael Hoa, M.D.

Auditory Development and Restoration Program


Building 35A Room 1F-266
Convent Drive MSC3745
Bethesda MD 20892
Office: 301-435-3455


michael.hoa@nih.gov

Dr. Hoa received a B.A. from Boston University and an M.D. from Boston University School of Medicine. He completed an Otolaryngology-Head and Neck Surgery residency at Wayne State University; a Neurotology fellowship at House Ear Clinic; and a T32 USC/HRI Hearing and Communications Neuroscience Postdoctoral Research Training Fellowship. Dr. Hoa studied mechanisms responsible for the development of the organ of Corti and auditory regeneration in the laboratory of Neil Segil, Ph.D., where he used a combination of fluorescent-activated cell sorting (FACS), confocal microscopy, and live culture systems to investigate mechanisms relating to hair cell regeneration in the perinatal mouse. Along with Fred Linthicum, Saumil Merchant, and Dr. Segil, Dr. Hoa demonstrated the survival of cochlear supporting cells from human temporal bones obtained from individuals who are profoundly deaf—demonstrating that supporting cells might serve as targets for future attempts at hair cell regeneration in humans. Previous work by others has demonstrated that mammalian cochlear supporting cells can be transdifferentiated into hair cells under certain unusual conditions. Dr. Hoa joined the NIDCD as an otolaryngology surgeon-scientist in 2013.



The Auditory Development and Restoration Program investigates the development and function of adult cochlear cell types and the pathophysiological processes that result in their structural and functional degeneration. The long-term goal of the laboratory is to establish a basis for hearing restoration in the adult inner ear.

The endocochlear potential (EP) is essential for proper hair cell function and hearing. The structure and function of the lateral wall of the cochlea is central to the generation of this endocochlear potential. With this in mind, the lab seeks to understand (1) the genetic mechanisms responsible for generation of the endocochlear potential and the necessary cell-type specific context of these genetic mechanisms in the stria vascularis; and (2) the mechanisms responsible for EP degeneration. Pathophysiology of the lateral wall has been implicated in age-related hearing loss (presbycusis), sudden sensorineural hearing loss, Ménière's disease, DFN3, and a diverse spectrum of inherited disorders, including Jervell and Lange-Nielson syndrome, Bartter syndrome, SeSAME syndrome, and Waardenburg syndrome. Ultimately, the lab’s research seeks to improve our understanding of the development and function of the stria vascularis. Investigations may provide insight into hearing loss related to pathology in the cochlear lateral wall, as well as potential avenues for therapeutic targeting of this pathology.

The model system used to study the stria vascularis in the cochlear lateral wall is the mouse. The stria vascularis is composed of 3 cell layers consisting of marginal cells on the luminal surface, intermediate cells in central layer, and basal cells in the basolateral layer. The intermediate cell is fundamental to the generation of the EP, but it is the close interaction between the 3 cell types that results in a fully functional organ. To investigate these interactions, the lab uses a combination of single-cell mRNA-sequencing, bioinformatics, fluorescence-activated cell sorting (FACS), adult and perinatal immunohistochemistry, confocal microscopy, animal auditory function testing, pharmacology, and molecular biology techniques.

Staff Image
  • Soumya Korrapati, Ph.D.
    Biologist

  • Rafal Olszewski, Ph.D.
    Biologist

  • 1) Nakanishi N, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ (2017)
  • NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy
  • Proc Natl Acad Sci U S A, 114(37), E7766-E7775
  • 2) Burns JC, Kelly MC, Hoa M, Morell RJ, Kelley MW. (2015)
  • Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear.
  • Nat Commun., 6: 8557.
  • 3) Hoa M, Friedman RA, Fisher LM, Derebery MJ. (2015)
  • Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere’s disease.
  • Laryngoscope , Sep 7. doi: 10.1002/lary.25579., [Epub ahead of print].
  • 4) Hoa M, Wilkinson EP, Slattery WH 3rd. (2014)
  • Delayed recovery of speech discrimination after fractionated stereotactic radiotherapy for vestibular schwannoma in neurofibromatosis 2.
  • Ear Nose Throat J. , 93(2):E20-2.
  • 5) Dhillon VK, Hoa M, Winter M, Wilkinson EP. (2014)
  • Extrusion of a cochlear implant positioner through the tympanic membrane in a pediatric patient: Management of a delayed complication.
  • Ann Otol Rhinol Laryngol., 123(8): 537-540.
  • 6) Friedman RA, Hoa M, Brackmann DE. (2013)
  • Surgical management of endolymphatic sac tumors.
  • J Neurol Surg B., 74(01):012-019, DOI: 10.1055/s-0032-1329622
  • 7) Hoa M, House JW, Linthicum FH Jr., Go JL. (2013)
  • Petrous apex cholesterol granuloma: Pictorial review of radiologic considerations in diagnosis and surgical histopathology.
  • J Laryngol Otol., 127(4): 339-48.
  • 8) Hoa M, Linthicum FH Jr. (2013)
  • Spiral ganglion deficiency in adult-onset deafness-dystonia syndrome.
  • Otol Neurotol., 34(9): e130-1. , doi: 10.1097/MAO.0b013e3182a09b3b
  • 9) Hoa M, Slattery WH 3rd. (2012)
  • Update on neurofibromatosis 2.
  • Otolaryngol Clin N Am., 45(2):315-32, viii.
  • 10) Hoa M, House JW, Linthicum FH Jr. (2012)
  • Petrous apex cholesterol granuloma: Maintenance of the drainage pathway, the histopathology of surgical management, and histopathologic evidence for the exposed marrow theory.
  • Otol Neurotol., 33(6):1059-65.
  • 11) Hoa M, Drazin D, Hanna G, Schwartz M, Lekovic GP. (2012)
  • The approach to the patient with incidentally diagnosed vestibular schwannoma.
  • Neurosurg Focus, 33(3):E2.
  • 12) Slattery WH, Hoa M, Bonne N, Friedman RA, Schwartz MS, Fisher L, Brackman DE. (2011)
  • Middle fossa decompression for hearing preservation: A review of institutional results and indications.
  • Otol Neurotol., 32(6):1017-24.
  • 13) Wilkinson EP, Hoa M, Slattery WH 3rd, Fayad JN, Friedman RA, Brackmann DE. (2011)
  • Evolution in the management of facial nerve schwannoma.
  • Laryngoscope , 121(10):2065-74.
  • 14) Hoa M, Syamal M, Schaeffer MA, Sachdeva L, Berk R, Coticchia J. (2010)
  • Biofilms and chronic otitis media: An initial exploration into the role of biofilms in the pathogenesis of chronic otitis media.
  • Am J Otolaryngol., 31(4):241-5.
View Pubmed Publication