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Senior Investigator

Mark P. Mattson, Ph.D.

Laboratory of Neurosciences, NIA Biomedical
251 Bayview Boulevard
Baltimore MD 212224
Office: (410) 558-8462

Fax: (410) 558-8465

Dr. Mattson received his PhD from the University of Iowa and postdoctoral training in developmental neurobiology with Stan Kater at Colorado State University. He then joined the faculty at the Sanders-Brown Center on Aging at the University of Kentucky where he studied neuronal plasticity and the pathogenesis of neurodegenerative disorders. In 2000, Dr. Mattson became Chief of the Laboratory of Neurosciences at the NIA Gerontology Research Center in Baltimore, and a Professor in the Department of Neuroscience at the Johns Hopkins University. He is editor of numerous journals, and has received many awards including the Metropolitan Life Foundation Award and the Alzheimer's Association Zenith Award. Dr. Mattson's laboratory is studying the molecular and cellular mechanisms responsible for neuronal dysfunction and death in age-related neurological disorders, and is working to identify environmental and genetic factors that allow individuals to age successfully with little or no brain dysfunction.

Staff Image
  • Kristen Alexander, B.S.
    Editorial Assistant

  • Uri Ashery, Ph.D.
    Visiting Scientist

  • Simonetta Camandola, Ph.D.
    Staff Scientist

  • Aiwu Cheng, Ph.D.
    Research Scientist

  • Roy Cutler, M.S.

  • Richard Flannery, Ph.D.
    Visiting Fellow

  • Marc Gleichmann, M.D., Ph.D.
    Visiting Fellow

  • Kathy Grifioen, Ph.D.
    Visiting Fellow

  • Seema Gulyani, Ph.D.
    Visiting Scientist

  • Emmette Hutchison, Ph.D.
    Candidate, GPP Brown University

  • Haiyang Jiang, B.S.
    Research Technician

  • Elisa Kawamoto, Ph.D.
    Visiting Fellow

  • Dong Liu, Ph.D.

  • Yongquan Luo, Ph.D.

  • Bronwen Martin, Ph.D.
    Visiting Fellow

  • Mohamed Mughal, M.S.
    Animal Studies Coordinator

  • Eric Norman, Ph.D.
    Visiting Fellow

  • Eitan Okun, Ph.D.
    Visiting Fellow

  • Xin Ouyang, B.S.
    Research Technician

  • Catherine Schwartz, Ph.D.
    Candidate, GPP Karolinska

  • Alexis Stranahan, Ph.D.
    Visiting Fellow

  • Ruiqian Wan, Ph.D.

  • Yue Wang, M.D., Ph.D.
    Staff Scientist

  • Jenq-Lin Yang, Ph.D.
    Visiting Fellow

  • Peisu Zhang, M.S.

  • 1) Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP (2008)
  • Diabetes impairs hippocampal function via glucocorticoid-mediated effects on new and mature neurons.
  • Nature Neurosci., 11, 309-317
  • 2) Xu X, Zhan M, Duan W, Prabhu V, Brenneman R, Wood W, Firman J, Li H, Zhang P, Ibe C, Zonderman AB, Longo DL, Poosala S, Becker KG, Mattson MP (2007)
  • Gene expression atlas of the mouse central nervous system: Impact and interactions of age, energy intake and gender.
  • Genome Biol., 8, R234
  • 3) Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, Jo DG, Lathia JD, Siler DA, Chigurupati S, Ouyang X, Magnus T, Camandola S, Mattson MP (2007)
  • Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits.
  • PNAS, 104, 13798-13803
  • 4) Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Gleichmann M, Cheng A, Okun E, Dixit VD, Chigurupati S, Mughal M, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP (2006)
  • Gamma secretase-mediated notch signaling worsens brain damage and functional outcome in ischemic stroke.
  • Nature Med., 12, 621-623
  • 5) Mattson MP, Cheng A (2006)
  • Neurohormetic phytochemicals: low dose toxins that induce adaptive neuronal stress responses.
  • Trends Neurosci., 29, 632-639
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