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Senior Investigator

Mark Hoon, Ph.D.

Molecular Genetics Unit

Laboratory of Sensory Biology
Building 35 Room 3F145
35A Convent Drive MSC3757
Bethesda MD 20892
Office: (301) 402-6613

Fax: (301) 480-3590
mhoon@dir.nidcr.nih.gov

Mark Hoon earned his PhD. at the University of Leeds in the lab of John Findlay where he studied the molecular components in invertebrate vision. After completing a NATO postdoc in Freiburg Germany he joined Nicholas Ryba's lab (NIDCR) investigating taste. Over a period of 15 years and in collaboration with Charles Zuker they discovered the receptors and cells required for sweet, bitter, and sour taste. At the end of 2006, Dr. Hoon started his own lab working on deciphering signaling pathways involved in mammalian somatosensation. The lab has been dissecting the cellular basis for thermosensation and pain signaling. Recently by studying neuropeptides they uncovered the neural pathway for itch. Dr. Hoon's group is continuing to study peripheral mechanism of somatosensation using molecular genetic techniques.



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  • 1) Yarmolinsky DA, Peng Y, Pogorzala LA, Rutlin M, Hoon MA, Zuker CS (2016)
  • Coding and Plasticity in the Mammalian Thermosensory System
  • Neuron, 92, 1079-1092
  • 2) Ran C, Hoon MA, Chen X (2016)
  • The coding of cutaneous temperature in the spinal cord.
  • Nature Neuroscience, 19, 1201-1209
  • 3) Hoon MA (2015)
  • Molecular dissection of itch
  • Curr Opin Neurobiol, 34, 61-66
  • 4) Mishra SK and Hoon, MA. (2013)
  • The Cells and Circuitry for Itch Responses in Mice
  • Science , 340, 968-71
  • 5) Pogorzalla L, Mishra SK and Hoon MA. (2013)
  • The cellular code for mammalian thermosensation.
  • Journal of Neuroscience, 2013 33, 5533-41
  • 6) Mishra SK, Holzman S and Hoon MA. (2012)
  • A nociceptive signaling role for neuromedin B.
  • Journal of Neuroscience, 32, 8686-95
  • 7) Mishra SK, Tisel S, Orestes P, Bhangoo S, Hoon MA. (2011)
  • TrpV1-lineage neurons are required for thermal sensation.
  • EMBO Journal, 30, 582-93
  • 8) Mishra SK & Hoon MA. (2010)
  • Ablation of TrpV1 neurons reveal their selective role in thermal pain sensation.
  • Molecular and Cellular Neuroscience, 43, 167-172
  • 9) Chandrashekar, J., Hoon, M. A., Ryba, N. J. P., Zuker, C. S. (2006)
  • The Biology of Mammalian Taste Receptors and Cells.
  • Nature , 444, 288-294
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