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Investigator

Mark H. Histed, Ph.D.

Unit on Neural Computation and Behavior

Porter Neuroscience Building
Building 35 Room 3A203
35 Convent Dr MSC 3703
Bethesda MD 20892
Office: 301 402 9208


mark.histed@nih.gov

Dr. Histed received a Ph.D. from the Massachusetts Institute of Technology, where with Earl K. Miller he studied how frontal and basal ganglia neuronal activity underlies complex behaviors. He did postdoctoral work at Harvard and the University of Chicago, with R. Clay Reid and John H.R. Maunsell, studying how the cerebral cortex represents the sensory world and developing psychophysical methods to measure perceptual behavior in rodents. Dr. Histed joined NIMH as an investigator in 2016.



A single sensory stimulus or motor action changes the activity of thousands or more neurons in the mammalian cerebral cortex. Dr. Histed’s group uses sensory behavior in the mouse, combined with in vivo electrophysiology, optogenetics, and two-photon imaging, to understand how the brain interprets the activity of many cells --- how the brain decodes neurons' spikes to make decisions.

Staff Image
  • Bradley Akitake, Ph.D.
    Research Scientist

  • Samuel Duffy, Ph.D.
    Post baccalaureate Fellow

  • Caitlin Leedy, B.S.
    Post baccalaureate Fellow

  • Anna Li
    Student Fellow

  • Lauren Ryan, B.S.
    Post baccalaureate Fellow

  • Alessandro Sanzeni, Ph.D.
    Research Fellow

  • 1) Histed MH, Maunsell JHR (2014)
  • Cortical neuronal networks can integrate inputs linearly, independent of synchrony
  • Proc Natl Acad Sci USA , Jan 7;111(1), E178-87. PMID: 24367105
  • 2) Glickfeld LL*, Histed MH*, Maunsell JHR (2013)
  • Mouse primary visual cortex is used to detect both orientation and contrast changes
  • J Neurosci 2013 Dec 11, 33(50), :19416-22. PMID: 24336708
  • 3) Histed MH, Ni AM, Maunsell JHR (2012)
  • Insights into the cortical mechanisms of behavior from microstimulation experiments
  • Prog Neurobiol 2012 Jan 28, PMID: 22307059
  • 4) Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed MH, Lois C, Ohki K (2012)
  • Similarity of visual selectivity among clonally related neurons in visual cortex
  • Neuron, 2012 Jul 12; 75(1):65-72 PMID: 22794261
  • 5) Histed MH, Carvalho LA, Maunsell JHR (2012)
  • Psychophysical measurement of contrast thresholds in the behaving mouse
  • J Neurophysiol, 2012 Feb., 107(3):758-65 PMID: 22049334
  • 6) Bonin V, Histed MH, Yurgenson S, and Reid RC (2011)
  • Local diversity and fine-scale organization of receptive fields in mouse visual cortex
  • J Neurosci 2011 Dec 14, 31(50), 18506-21. PMID: 22171051
  • 7) Histed MH, Bonin V, and Reid RC (2009)
  • Direct activation of sparse, distributed sets of cortical neurons with electrical microstimulation
  • Neuron 2009 Aug 27, 63(4), 508-22. PMID: 19709632
  • 8) Histed MH*, Pasupathy A*, and Miller EK (2009)
  • Learning substrates in the primate prefrontal cortex and striatum: sustained activity related to successful actions
  • Neuron 2009 Jul 30, 63(2);244-53, PMID: 19640482
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