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Staff Clinician

Lauren Bowen Reoma, M.D.

Clinical Trials Unit

Building 10
Center Drive
Bethesda MD 20892
Office: (301)435-7531

Dr. Lauren Bowen Reoma is a Staff Clinician and Medical Director of the NINDS Clinical Trials Unit in the Office of the Clinical Director where she oversees the centralized support for NINDS sponsored IND and IDE clinical trials and Data and Safety Monitoring procedures, as well as serves as the Medical Monitor for selected NINDS sponsored trials. She is a board-certified neurologist who received her medical degree from the University of Florida in May 2011. She completed her Internal Medicine Internship at the University of Florida College of Medicine in 2012 and completed her neurology residency at the University of Florida College of Medicine in 2015. From 2015-2019, she trained as a Clinical Fellow in the NINDS Neuroimmunology and Neurovirology Program where she completed additional training in Clinical Trials Methodology and the FDA Clinical Investigator Training.

Dr. Reoma research focuses on the role of viruses, the immune system, and the interplay between these two within the central nervous system. She completed a clinical research fellowship in the Neuroimmunology and Neurovirology Program at NINDS under Dr. Avindra Nath, from 2015-2019, where she gained an expertise in infections of the central nervous system, neuroimmunology, clinical trials methodology, and oversight of IND-regulated clinical trials. She is a member of the AIDS Clinical Trials Group (ACTG) End-organ Disease, the Inflammation Transformative Science Group and the ACTG Neurology Collaborative Science Group, and American Academy of Neurology. She is the lead investigator on an FDA regulated clinical study NCT03239899: PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection and is an investigator on several intramural studies. She has published in the field of neurovirology and neuroimmunology.

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  • 1) Henderson LJ, Reoma LB, Kovacs JA, Nath A (2020)
  • Advances toward Curing HIV-1 Infection in Tissue Reservoirs
  • J Virol, 2020 Jan 17;94(3). doi: 10.1128/JVI.00375-19. Prin, Review. PubMed PMID: 31694954; PubMed Central PMCI
  • 2) Cortese I, Muranski P, Akahata Y, Ha SK, Smith B, Monaco MC, Ryschewitsch C, Major EO, Ohayon J, Schindler M, Beck E, Reoma LB, Jacobson S, Reich DS, Nath A (2019)
  • Treatment of progressive multifocal leukoencephalopathy with a checkpoint-inhibitor
  • NEJM, 2019 Apr 10, doi: 10.1056/NEJMoa1815039
  • 3) Cortese I, Muranski P, Enose-Akahata Y, Ha SK, Smith B, Monaco M, Ryschkewitsch C, Major EO, Ohayon J, Schindler MK, Beck E, Reoma LB, Jacobson S, Reich DS, Nath A. (2019)
  • Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy
  • N Engl J Med, 2019 Apr 25;380(17):1597-1605. doi: 10.1056/NEJMoa, Epub 2019 Apr 10. PubMed PMID: 30969503.
  • 4) Henderson LJ, Johnson TP, Smith BR, Reoma LB, Santamaria UA, Bachani M, Demarino C, Barclay RA, Snow J, Sacktor N, Mcarthur J, Letendre S, Steiner J, Kashanchi F, Nath A (2019)
  • Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
  • AIDS, 2019 Dec 1;33 Suppl 2:S145-S157. doi: 10.1097/QAD., PubMed PMID: 31789815
  • 5) Reoma LB, Trindade CJ, Monaco MC, Solis J, Montojo MG, Vu P, Johnson K, Beck E, Nair G, Khan OI, Quezado M, Hewitt SM, Reich DS, Childs R, Nath A (2019)
  • Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy
  • Ann Neurol, 2019 Dec;86(6):878-884. doi: 10.1002/ana.25608, Epub 2019 Oct 16. PubMed PMID: 31600832
  • 6) Bowen LN, Tyagi R, Li W, Alfahad T, Smith B, Wright M, Singer E, Nath A (2016)
  • HIV-associated Motor Neuron Disease: HERV-K Activation and response to anti-retroviral therapy
  • Neurology, 87, 1–7
  • 7) Margaret Gatti-Mays MD MPH, Maura Manion MD, Lauren Bowen MD, G. Thomas Brown, MD PhD, Robert Danner MD, Omar Khan MD, Avindra Nath MD, Minoo Battiwalla MD, Austin John Barrett MD, Sawa Ito MD (2016)
  • Toxoplasmosis Encephalitis with Immune-Reconstitution Inflammatory Syndrome in an allogeneic stem cell transplant patient
  • . Bone Marrow Transplant, 2016 Dec;51(12), 1622-1624
  • 8) Bowen LN, Smith B, Reich D, Quezado M, Nath A (2016)
  • Opportunistic CNS Infections in HIV-infected individuals
  • Nat Rev Neurol, 2016 Oct 27, 12(11):662-674
  • 9) Bowen LN, S.H. Subramony MD, Kenneth M. Heilman MD (2015)
  • Apraxia in Anti-GAD Associated Stiff Person Syndrome: Link to Corticobasal Degeneration?
  • Ann Neurol, 2015 Jan;77(1), 173-6
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