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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Investigator

Jun Shen, Ph.D.

Mood and Anxiety Disorders Program
Building 10 Room 2D51A
10 Center Drive MSC1527
Bethesda MD 20892-1527
Office: (301) 451-3408

Fax: (301) 480-2397
shenj@intra.nimh.nih.gov

Dr. Shen received his B. S. in 1985 from Nankai University. In 1995 he received his Ph.D. from the University of Wisconsin, where he worked with Laura Lerner studying high-resolution NMR spectroscopy and conformational analysis of carbohydrates. He did postdoctoral training on in vivo magnetic resonance spectroscopy with Robert Shulman and Douglas Rothman at the Yale University School of Medicine. In 1996 Dr. Shen became a staff member in the Internal Medicine Department and the Magnetic Resonance Center at Yale. In 1998 he joined the faculty in the Radiology Department at New York University Medical School and the Medical Physics Division at the Nathan Kline Institute. Dr. Shen joined the NIMH as an Investigator in 2002.



Dr. Shen research at the NIMH focuses on non-invasive in vivo nuclear magnetic resonance spectroscopy technology development and applications. Dr. Shen's group is interested in applying advanced proton and heteronuclear magnetic resonance techniques to studying neurometabolism and neurotransmission of glutamate and GABA in normal brain function and in neuropsychiatric disorders.

Staff Image
  • Li An, Ph.D.
    Staff Scientist
    (301) 594-6868

  • Christopher Johnson, B.S.
    Laboratory Technician
    (301) 402-6695

  • Ningzhi Li, Ph.D.
    Research Fellow
    301-594-0962

  • 1) N. Li, S. Li, and J. Shen (2017)
  • In vivo 13C magnetic resonance spectroscopy by random radiofrequency heteronuclear decoupling and data undersampling
  • Front. Phys., 5, 26:1-16
  • 2) An, S. Li, and J. Shen (2017)
  • Simultaneous determination of metabolite concentration, T1 and T2 relaxation times
  • Magn. Reson. Med., 78, 2072–2081
  • 3) Y. Zhang, L. An, and J. Shen (2017)
  • Fast computation of full density matrix of multispin systems for spatially localized in vivo magnetic resonance spectroscopy
  • Med. Phys, 44, 4169-4178
  • 4) N. Lally, L. An, D. Bannerjee, M.J. Niciu Jr., D. Luckenbaugh, E. Richards, J.P. Roiser, J. Shen, C.A. Zarate Jr., A.C. Nugent (2016)
  • Reliability of 1H-MRS measured human prefrontal cortex glutamatergic signals at 7 Tesla: a between and within session investigation
  • J. Magn. Reson. Imaging, 43, 88-98
  • 5) S. Marenco, C. Meyer, S. Kuo, J.W. van der Veen, J. Shen, K. DeJong, A.S. Barnett, J.A. Apud, D. Dickinson, D.R. Weinberger, and K.F. Berman (2016)
  • Prefrontal GABA levels measured with magnetic resonance spectroscopy in patients with psychosis and unaffected siblings
  • Am. J. Psychiatry, 173, 527-534
View Pubmed Publication