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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Senior Investigator

Jean Lud Cadet, M.D.

Molecular Neuropsychiatry Research Branch


Room 07A721A
251 Bayview Boulevard Suite 200
Baltimore MD 21224
Office: 443-740-2656
Lab: 443-740-2656
Fax: 443-740-2856
jcadet@intra.nida.nih.gov

Jean Lud Cadet, M.D., Chief, Molecular Neuropsychiatry Research Branch and Associate Director for Diversity and Outreach at NIDA.

M.D.: Columbia University College of Physicians and Surgeons


Residencies:

Department of Psychiatry at Columbia University College of Physicians and Surgeons

Department of Neurology at Mount Sinai Medical Center in NYC

Post-Doctoral Fellowship: Neuropsychiatry Branch, NIMH



The research in Dr. Cadet’s section focuses on studies of the molecular and cellular mechanisms of psychostimulant addiction and toxicity. Dr. Cadet’s group has provided recent evidence that methamphetamine (METH) self-administration is accompanied with markers of toxicity in striatal dopaminergic systems. These results are consistent with the idea that catecholamines, especially, dopamine can activate neurodegenerative processes in the mammalian brain. They have also shown recently that METH preconditioning protects against METH toxicity. This occurs by upregulation of neurotrophic factors such as BDNF and/or downregulation of glutamatergic systems. Preliminary studies have shown that these changes are secondary to epigenetic modifications that include histone hypoacetylation and DNA methylation. The laboratory is thus pursuing investigations to further identify epigenetic markers that are involved in METH self-administration and METH preconditioning.

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  • 1) Torres OV, Ladenheim B, Jayanthi S, McCoy MT, Krasnova IN, Vautier FA, Cadet JL (2016)
  • An Acute Methamphetamine Injection Downregulates the Expression of Several Histone Deacetylases (HDACs) in the Mouse Nucleus Accumbens: Potential Regulatory Role of HDAC2 Expression
  • Neurotox Res, . 2016 Jul;30(1):32-40. doi: 10.1007/s12640-015-95, Epub 2015 Dec 31
  • 2) Krasnova, I.N., Ladenheim, B., Cadet, J.L (2005)
  • Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway
  • FASEB J, 19, 851-853
  • 3) Jayanthi, S., Deng, X., Ladenheim, B., McCoy, M.T., Cluster, A., Cai, N.S., Cadet, J.L (2005)
  • Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
  • Proc Natl Acad Sci, 102, 868-873
View Pubmed Publication