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Henriette van Praag, Ph.D.

Biomedical Research Center
Room 5B123
Laboratory of Neurosciences, 251 Bayview Boulevard
Baltimore MD 21224-
Office: 410-558-8064
Lab: 301-281-1707 /

Henriette van Praag received her Ph.D. from Tel-Aviv University in 1992 for her work studying opiate receptor function. She did her postdoctoral research on the role of nerve growth factors in brain injury at Robert Wood Johnson Medical School from 1992-1997. She continued her research in brain regeneration as a staff scientist at the Salk Institute for Biological Studies, where she found that exercise plays an important role in the production of new neurons in the adult rodent brain. She joined NIA in 2007. Her laboratory studies the functional integration of newly born neurons into the hippocampal circuitry using viral vectors and investigates the contribution of adult neurogenesis to learning and memory.

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  • 1) Cooper C, Moon HY, van Praag H (2017)
  • On the Run for Hippocampal Plasticity
  • Cold Spring Harb Perspect Med, 2017 May 11. pii: a029736, doi: 10.1101/cshperspect. a029736
  • 2) Sah N, Peterson BD, Lubejko ST, Vivar C, van Praag H (2017)
  • Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons
  • Sci Rep, 2017 Sep 7;7(1):10903, doi: 10.1038/s41598-017-11268-z
  • 3) Jongbloets, B.C., Lemstra, S., Schellino, R., Broekhoven, M.H., Hellemons, A.J., Giacobini, P., Mao, T., van Praag, H., De Marchis, S., Ramakers, G.M., Pasterkamp, R.J (2017)
  • Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
  • Nature Communications, 2017 in press
  • 4) Mohammad H, Marchisella F, Ortega-Martinez S, Hollos P, Eerola K, Komulainen E, Kulesskaya N, Freemantle E, Fagerholm V, Savontous E, Rauvala H, Peterson BD, van Praag H, Coffey ET (2016)
  • JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche
  • Molecular Psychiatry, 2016 Nov 15. doi: 10.1038/mp.2016.203
  • 5) Moon HY, Becke A, Berron D, Becker B, Sah N, Benoni G, Janke E, Lubejko ST, Greig NH, Mattison JA, Duzel E, van Praag H. (2016)
  • Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.
  • Cell Metab. 2016 Jun 21. pii: S1550-4131(16)30247-9. doi: 10.1016/j.cmet.2016.05.025.
  • 6) E Duzel, H van Praag, M Sendtner (2016)
  • Can physical exercise in old age improve memory and hippocampal function?
  • Brain
  • 7) Vivar, C., Peterson, B.D., van Praag, H (2015)
  • Running rewires the neuronal network of adult-born granule cells
  • NeuroImage
  • 8) Davide Guerrieri, Henriette van Praag (2015)
  • Exercise-mimetic AICAR transiently benefits brain function
  • Oncotarget, Advance Publications
  • 9) Stringer TP, Guerrieri D, Vivar C, van Praag H (2015)
  • Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice
  • Transl. Psychiatry, 5:e493. , doi: 10.1038/tp.2014.135.
  • 10) Moon HY, van Praag H (2014)
  • Muscle over mind
  • Cell Metabolism , 20(4):560-562
  • 11) Zhang Z, van Praag H (2014)
  • Maternal immune activation differentially impacts mature and adult-born hippocampal neurons in male mice
  • Brain Behav. Immun, pii: S0889-1591(14)00507-8
  • 12) Kobilo T, Guerrieri D, Zhang Y, Collica SC, Becker KG, van Praag H (2014)
  • AMPK agonist AICAR improves cognition and motor coordination in young and aged mice
  • Learning and Memory, 21, 119-126
  • 13) Voss M.W., Vivar C., Kramer A.F., van Praag H. (2013)
  • Bridging animal and human models of exercise-induced brain plasticity
  • Trends in Cognitive Sciences
  • 14) Marlatt, M.W., Potter, M.C., Lucassen, P.J., van Praag H (2012)
  • Running throughout middle-age improves memory function, hippocampal neurogenesis and BDNF levels in female C57Bl/6J mice
  • Dev. Neurobiology, 72:943-952
  • 15) Vivar, C., Potter, M.C., Choi, J., Lee, J.Y., Stringer, T.P., Callaway, E.M., Gage, F.H., Suh, H., van Praag, H. (2012)
  • Monosynaptic inputs to new neurons in the dentate gyrus.
  • Nature Communications 3:1107 , doi: 10.1038/ncomms2101
  • 16) Kobilo, K., Liu, Q.R., Gandhi, K., Mughal, M., Shaham, Y., van Praag, H. (2012)
  • Running is the Neurogenic and Neurotrophic Stimulus in Environmental Enrichment
  • Learning and Memory, 18: 605-609
  • 17) Kobilo T, Yuan C, van Praag H (2011)
  • Endurance factors improve hippocampal neurogenesis and spatial memory in mice
  • Learning and Memory, 18, 103-107
  • 18) Potter MC, Yuan C, Ottenritter C, Mughal M, van Praag H (2010)
  • Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington's disease
  • PLoS Curr., 7, 2:RRN1201
  • 19) Marlatt MW, Lucassen PJ, van Praag H (2010)
  • Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice
  • Brain Research, 1341, 93-99
  • 20) Creer DJ, Romberg C, Saksida LM, van Praag H, Bussey TJ (2010)
  • Running Enhances Spatial Pattern Separation in Mice
  • Proceedings of the National Academy of Sciences, 107(5), 2367-2372
  • 21) van Praag H (2009)
  • Exercise and the brain: something to chew on
  • Trends in Neurosciences, 32, 283-290
  • 22) van Praag, H. (2008)
  • Neurogenesis and Exercise: Past and Future Directions
  • Neuromolecular Medicine, 10(2), 128-140
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