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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Investigator

Doris K. Wu, Ph.D.

Laboratory of Molecular Biology
Room 2B34
5 Research Court MSC3320
Rockville MD 20850-3320
Office: (301) 402-4214

Fax: (301) 402-5475
wud@nidcd.nih.gov

Dr. Doris Wu received her B.S. degree from University of Wisconsin in 1976 and her M.S. from University of Southern California in 1978. She received her Ph.D. in 1983 from University of California, Los Angeles, where she studied the regulation of catecholamine-sensitive adenylate cyclase in glial cells. In 1987, she joined Connie Cepko's laboratory at Harvard University studying cell type determination in the vertebrate retina. She moved to NIDCD in 1993, and her laboratory is studying molecular mechanisms governing morphogenesis of the vertebrate inner ear.



The main focus of our laboratory is to identify genes important in the development of the vertebrate inner ear. We utilize avian retroviral vectors available in chicken as well as transgenic and knock out mouse models as tools to investigate the role of specific genes during inner ear development.






Lateral views of paint-filled mouse inner ears

Membranous labyrinths of mouse inner ears at various stages of development were microinjected with latex paint solution

Lateral views of paint-filled mouse inner ears

Membranous labyrinths of mouse inner ears at various stages of development were microinjected with latex paint solution

Staff Image
  • Jenny Bai, M.D.
    Postdoctoral Fellow
    (301) 402-4215

  • Raquel Cantos, Ph.D.
    Postdoctoral Fellow
    (301) 402-4215

  • Weise Chang, Ph.D.
    Research Fellow
    (301) 402-4215

  • Omar Howard, B.S.
    Predoctoral Fellow
    (301) 402-4215

  • Michael Mulheisen, M.S.
    Research Assistant
    (301) 402-4215

  • Bing Wen
    Student
    (301) 402-4215

  • 1) Cantos, R., Cole, L., Acampora, D, Simeone, A. and Wu, D. K. (2000)
  • Patterning of the mammalian cochlea
  • PNAS, 97, 11707-11713
  • 2) Morsli, H., Tuorto, F., Choo, D., Postiglione, P., Simeone, A. and Wu, D.K. (1999)
  • Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
  • Development, 126, 2335-2343
  • 3) Chang, W., Nunes, F., De Jesus-Escobar, J. M., Harland, R. and Wu, D. K. (1999)
  • Ectopic Noggin blocks sensory and non-sensory organ morphogenesis in the chicken inner ear
  • Dev Bio, 216, 369-381
  • 4) Morsli, H., Choo, D., Ryan, A., Johnson, R. and Wu, D.K. (1998)
  • Development of the mouse inner ear and origin of its sensory organs
  • J. Neurosci, 18, 3327-3335
  • 5) Wu, D.K., Nunes, F., and Choo, D. (1998)
  • Axial specification for sensory organs versus non-sensory structures of the chicken inner ear
  • Development, 125, 11-20
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