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Senior Investigator

David S. Goldstein, M.D., Ph.D.

Autonomic Medicine Section

Clinical Neurocardiology Section, CNP
Building 10 Room 5N220
9000 Rockville Pike
10 Center Drive
MSC 1620
Bethesda MD 20892-1620
Office: (301) 496-2103
Lab: (301) 496-7832
Fax: (301) 402-0180
goldsteind@ninds.nih.gov

Dr. Goldstein graduated from Yale in 1970 and received an M.D.-Ph.D. in Behavioral Sciences from Johns Hopkins in 1976. He came to the NIH as a Clinical Associate in the NHLBI in 1978 and became a Senior Investigator in 1984. He joined the NINDS in 1990 to head the Clinical Neurochemistry Section. In 1999 he founded the Clinical Neurocardiology Section, which was renamed the Autonomic Medicine Section in 2020. He has received Yale's Angier Prize for Research in Psychology, the Laufberger Medal of the Czech Academy of Sciences, 2 NIH Merit Awards, the Founders Award of the Bakken Heart-Brain Institute, the Distinguished Investigator Award of the Society for Clinical and Translational Science, and the NIH Distinguished Clinical Teacher Award. He has authored more than 600 scientific articles and several books, including Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine; Dysautonomias: A Handbook for Patients; Stress, Catecholamines, and Cardiovascular Disease; The Autonomic Nervous System in Health and Disease; and the e-book, "Principles of Autonomic Medicine. Dr. Goldstein directs the accredited Clinical Fellowship in Autonomic Disorders at the NIH. His research interests are on biomarkers, mechanisms, and treatments of catecholamine-related disorders. His main future goal is to establish autonomic medicine as a clinical scientific discipline.



Dr. Goldstein's research interests are in autonomic medicine and catecholamine-related disorders. The Clinical Neurocardiology Section, which he founded and directs, carries out mainly patient-oriented research. The Section operates a renowned Clinical Neurochemistry Laboratory for assays of levels of catecholamines and their metabolites. Current research of the Section focuses on biomarkers, mechanisms, and potential treatment of catecholaminergic neurodegeneration in Parkinson's disease and related disorders.



Clinical Protocol

  • Clinical Laboratory Evaluation of Chronic Autonomic Failure (18N0140)
  • Biomarkers of Risk of Parkinson Disease (09N0010)
  • Reference Values for Plasma Catechols (06N0047)
  • Repository Protocol (08NN090)
  • Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson’s Disease? (17N0076, inactive)
  • Clinical Autonomic Disorders: A Training Protocol (14N0122, inactive)
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  • Jamie Cherup, C-RNP
    Nurse Practitioner
    301-451-4041

  • Janna Gelsomino, R.N.
    Research Nurse
    301-435-5166

  • Courtney Holmes, C.M.T.
    Contractor
    (301) 496-7832

  • Risa Isonaka, Ph.D.
    Visiting Fellow

  • Patti Sullivan, CMT, ASCP
    Biologist
    (301) 402-2052

  • 2) Goldstein DS (2019)
  • How does homeostasis happen? Integrative physiologic, systems biologic, and evolutionary perspectives
  • Am J Physiol (Regul Integr Comp Physiol) , 316, R301-R317.(PMID 28918243)
  • 3) Goldstein DS, Pekker M, Eisenhofer G, Sharabi Y. (2019)
  • Computational modeling reveals multiple abnormalities of myocardial noradrenergic function in Lewy body diseases
  • JCI Insight , doi: 10.1172/jci.insight.130441, (PMID 31335324)
  • 4) Goldstein DS. (2013)
  • Dysautonomias: A Handbook for Patients, (available from the Author)
  • 5) Goldstein DS. (2013)
  • Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecholamine systems.
  • Compr Physiol, 3, 1569-1610. (PMID 24265239).
  • 6) Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong G, Mash DC, Kopin IJ, Sharabi Y. (2013)
  • Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson disease.
  • J Neurochem, 123, 591-603. (PMID: 23786406).
  • 7) Goldstein DS. (2006)
  • Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine
  • Johns Hopkins University Press
  • 8) Eisenhofer G, Kopin IJ, Goldstein DS. (2004)
  • Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
  • Pharmacol Rev, 56, 331-349
  • 9) Goldstein DS, Eisenhofer G, Kopin IJ. (2003)
  • Sources and significance of plasma levels of catechols and their metabolites in humans
  • J Pharmacol Exp Ther, 305, 800-811
  • 10) Goldstein DS, Smith LJ (2002)
  • The NDRF Handbook for Patients with Dysautonomias
  • Futura
  • 11) David S. Goldstein, MD, PhD; Discussants: David Robertson, MD; Murray Esler, MD; Stephen E. Straus, MD; and Graeme Eisenhofer, PhD (2002)
  • Dysautonomias: Clinical Disorders of the Autonomic Nervous System
  • Ann Intern Med. 2002, 137, 756-7
  • 12) Lenders JWM, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, Keiser HR, Goldstein DS, Eisenhofer G. (2002)
  • Biochemical diagnosis of pheochromocytoma: Which test is best?
  • JAMA, 287, 1427-1434
  • 13) Goldstein DS, Holmes C, Dendi R, Bruce S, Li S-T (2002)
  • Orthostatic hypotension from sympathetic denervation in Parkinson’s disease
  • Neurology, 58, 1247-1255
  • 14) Goldstein DS (2001)
  • The Autonomic Nervous System in Health and Disease
  • Taylor & Francis
  • 15) Eisenhofer G, Lenders JWM, Linehan WM, Walther MM, Goldstein DS, Keiser HR (1999)
  • Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2
  • N Engl J Med, 340, 1872-1879
  • 16) Goldstein DS, Holmes C, Cannon RO III, Eisenhofer G, Kopin IJ (1997)
  • Sympathetic cardioneuropathy in dysautonomias
  • N Engl J Med, 336, 696-702
  • 17) Goldstein DS (1997)
  • On the dialectic between molecular genetics and integrative physiology: Toward a new medical science
  • Perspectives Biol Med, 40, 505-515
  • 18) Goldstein DS, Lenders JWM, Kaler SG, Eisenhofer G. Catecholamine phenotyping: Clues to the diagnosis, treatment, and pathophysiology of neurogenetic disorders (1996)
  • Catecholamine phenotyping: Clues to the diagnosis, treatment, and pathophysiology of neurogenetic disorders
  • J Neurochem , 67, 1781-1790
  • 19) Goldstein DS (1995)
  • Stress, Catecholamines, and Cardiovascular Disease
  • Oxford Univ. Press
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