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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Investigator

Da-Ting Lin, Ph.D.

Neural Engineering Unit

Triad Technology Center
Room 2206
333 Cassell Drive
Baltimore MD 21224
Office: 443-740-2868
Lab: 443-740-2868

da-ting.lin@nih.gov

Post-doctoral Training - 2003-2010, Department of Neuroscience, Johns Hopkins University School of Medicine / HHMI; Advisor: Richard L. Huganir


Ph.D. - 2002, Cellular and Structural Biology, University of Texas Health Science Center at San Antonio. San Antonio, TX


B.S. - 1996, Biology, University of Science and Technology of China, Hefei, China



The research focus in the laboratory is to develop and apply in vivo optical imaging methods as well as computational method for data analysis, to disseminate neuronal circuit dysfunction leading to the development of long term drug addiction and relapse. Currently, the primary focus of the group is to develop the miniScope imaging system allowing simultaneous recording of activity of hundreds of neurons in deep brain regions of freely moving animals. In the long term, in vivo deep brain imaging and closed-loop feedback control of neuronal circuit activity, as well as closed-loop patterned optical of neuronal activity will be explored.

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  • 1) Zhang W, Daly KM, Liang B, Zhang L, Li X, Li Y, Lin DT (2017)
  • BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo
  • J Mol Cell Biol, 2017 Apr 1;9(2):117-131, doi: 10.1093/jmcb/mjw029
  • 2) Barbera G, Liang B, Zhang L, Gerfen CR, Culurciello E, Chen R, Li Y, Lin DT (2016)
  • Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information
  • Neuron, 2016 Oct 5;92(1):202-213. doi: 10.1016/j.neuron, 2016.08.037. Epub 2016 Sep 22. PMID: 27667003
  • 3) Zhang W, Zhang L, Liang B, Schroeder D, Zhang ZW, Cox GA, Li Y, Lin DT (2016)
  • Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders
  • Nat Neurosci, 2016 Apr;19(4):557-9, doi: 10.1038/nn.4257. Epub 2016 Feb 22
  • 4) Lee ST, Williams PA, Braine CE, Lin DT, John SW, Irazoqui PP (2015)
  • A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator
  • IEEE Trans Neural Syst Rehabil Eng, 2015 Jul;23(4):655-64, doi: 10.1109/TNSRE.2015.2391282. Epub 2015 Jan 15
  • 5) Zhang Y, Cudmore RH, Lin DT, Linden DJ, Huganir RL (2015)
  • Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo
  • Nat Neurosci, 2015 Mar;18(3):402-7, doi: 10.1038/nn.3936. Epub 2015 Feb 2
  • 6) Dickson PE, Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin DT, Chesler EJ (2015)
  • Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice
  • Psychopharmacology (Berl), 2015 Mar;232(6):1011-24, doi: 10.1007/s00213-014-3737-5. Epub 2014 Sep 20
  • 7) Li Y, Roy BD, Wang W, Zhang L, Zhang L, Sampson SB, Yang Y, Lin DT (2012)
  • Identification of two functionally distinct endosomal recycling pathways for dopamine D2 receptor
  • J Neurosci, 2012 May 23;32(21):7178-90, doi: 10.1523/JNEUROSCI.0008-12.2012
  • 8) Lin DT, Makino Y, Sharma K, Hayashi T, Neve R, Takamiya K, Huganir RL (2009)
  • Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
  • Nat Neurosci, Jul;12(7):879-87, doi: 10.1038/nn.2351. Epub 2009 Jun 7
  • 9) Lin DT, Wu J, Holstein D, Upadhyay G, Rourk W, Muller E, Lechleiter JD (2007)
  • Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes
  • Neurobiol Aging, Jan;28(1):99-111, Epub 2005 Dec 15
  • 10) Lin DT, Huganir RL (2007)
  • PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization
  • J Neurosci, Dec 12;27(50), 13903-8
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