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Postdoctoral Fellow

Christian Meisel, M.D.

Section on Critical Brain Dynamics

Laboratory of Systems Neuroscience
Building 35 Room 3A-114
35 Convent Drive
Bethesda MD 20892-3726
Office: (301) 402-6806
Lab: (301) 402-6806
Fax: (301) 480-7480

My research interests lie at the intersection between physics and medicine (specifically neurology). Over the last years I have focused on basic and translational research aspects with a particular emphasis on the function of sleep and focal epilepsy. There, a guiding principle has been the strong belief that, by bringing modern computational and theory-guided approaches to neurology, we will be able to significantly advance the understanding of normal and pathological brain function. This synthesis of computation and neurology is reflected in the term computational neurology ( My long-term translational goal is to leverage the insights gained by this approach and, consequently, enhance diagnostics and treatment options for epilepsy patients and in other neurological conditions. To this end, I am developing and applying novel tools from physics and dynamical systems theory for the analysis of neuronal activity patterns underlying these diseases.

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  • 1) C. Meisel (2016)
  • Linking cortical network synchrony and excitability.
  • Communicative & Integrative Biology , DOI:10.1080/19420889.2015.1128598 [OA]
  • 2) C. Meisel, D. Plenz, A. Schulze-Bonhage, H. Reichmann (2016)
  • Quantifying antiepileptic drug effects using intrinsic excitability measures.
  • Epilepsia, DOI: 10.1111/epi.13517
  • 3) C. Meisel, A. Klaus, D. Plenz (2016)
  • Sustained wakefulness shortens the intrinsic timescales of cortical dynamics.
  • Under review
  • 4) C. Meisel (2015)
  • Sleep, criticality and optimal information processing in cortical networks.
  • Front. of Hum. Neurosci., DOI: 10.3389/978-2-88919-522-0
  • 5) C. Meisel, A. Klaus, C. Kuehn and D. Plenz (2015)
  • Critical slowing governs the transition to neuronal spiking.
  • PLoS Computational Biology , 11(2), e1004097
  • 6) C. Meisel, A. Schulze-Bonhage, D. Freestone, M. Cook, P. Achermann and D. Plenz (2015)
  • Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability during the wake/sleep cycle.
  • Proc. Natl. Acad. Sci. U.S.A., 112(47), 14694-14699
  • 7) R. B. Yaffe, P. Borger, P. Megevand, D. M. Groppe, M. A. Kramer, C. J. Chu, S. Santaniello, C. Meisel, A. Mehta and S. V. Sarma (2014)
  • Physiology of functional and effective networks in epilepsy.
  • Clinical Neurophysiology, 126(2), 227-236
  • 8) Yokoyama, F. Ficara, M. J. Murphy, C. Meisel, C. Hatanaka, I. Kitabayashi, I. and M. L. Cleary (2013)
  • MLL becomes functional through intra-molecular interaction not by proteolytic processing.
  • PLoS ONE, 8(9), e73649
  • 9) C. Meisel, E. Olbrich, O. Shriki and P. Achermann (2013)
  • Fading signatures of critical brain dynamics during sustained wakefulness in humans.
  • J. Neurosci., 33(44), 17363-17372
  • 10) C. Meisel, A. Storch, S. Hallmeyer-Elgner, E. Bullmore and T. Gross (2012)
  • Failure of adaptive self-organized criticality during epileptic seizure attacks.
  • PLoS Comput. Biol., 8(1), e1002312
  • 11) C. Meisel and C. Kuehn (2012)
  • Scaling effects and spatio-temporal multilevel dynamics in epileptic seizures.
  • PLoS ONE, 7(2), e30371
  • 12) Meisel, C., Storch, A., Hallmeyer-Elgner, S., Bullmore, E., Gross, T. (2012)
  • Failure of Adaptive Self-Organized Criticality during Epileptic Seizure Attacks.
  • PLoS Comput. Biol., 8(1), e1002312.
  • 13) A. Yokoyama, F. Ficara, M. J. Murphy, C. Meisel, A. Naresh, I. Kitabayashi and M. L. Cleary (2011)
  • Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.
  • J. Cell. Sci., 124, 2208--2219
  • 14) C. Meisel and T. Gross (2009)
  • Adaptive self-organization in a realistic neural network model.
  • Physical Review E, 80(6), 061917
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