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NINDSNIMHNICHDNIDCDNEINIDCRNIANIAAANIDANHGRI NCCIHNIDDKNIEHSCCB

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Investigator

Brandon Harvey, Ph.D.

NIH Bayview Research Center
251 Bayview Boulevard, Suite 200, Room 06A729
Baltimore MD 21224
Office: 443-740-2590
Lab: 443-740-2590

bharvey@mail.nih.gov

Dr. Harvey received his Ph.D. in Neurobiology and Anatomy from the University of Rochester where he began his interest in gene delivery and gene therapy for the central nervous system. He joined NIDA in 2002 where he brought methods for viral vector production to the Neural Protection and Regeneration Section led by Dr. Yun Wang. Dr. Harvey’s experience with molecular biology and viral vectors coupled with his background in the models of neurodegeneration and neurotoxicity contribute to his directorship of the Optogenetics and Transgenic Technology Core where he develops genetic tools for monitoring and manipulating the activity of neurons and glia in the rodent central nervous system. Dr. Harvey also has an ongoing research project as part of the Cellular Protection and Repair (CPR) laboratory examining the protein Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) and its associated functions in the neuroprotection, ER stress, unfolded protein response (UPR) and the KDEL retrieval pathway.



  • The role of endoplasmic reticulum stress and inflammation in neuronal dysfunction caused by substance abuse or neurodegenerative diseases.
  • Identify and study the biology of secreted ER calcium modulated proteins (SERCaMPs) and KDEL receptors.
  • Examining the influence of drugs of abuse and SERCaMPs on microglial activation.
  • Developing genetic and pharmacological tools to monitor and modulate ER calcium.
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  • 1) Yu SJ, Wu KJ, Bae EK, Hsu MJ, Richie CT, Harvey BK, Wang Y (2014)
  • Methamphetamine induces a rapid increase of intracellular Ca++ levels in neurons overexpressing GCaMP5
  • Addict Biol, 2014 Nov 6. doi: 10.1111/adb.12193. , [Epub ahead of print]
  • 2) Sterky FH, Pernold K, Harvey BK, Lindqvist E, Hoffer BJ, Olson L. (2013)
  • Glial cell line-derived neurotrophic factor partially ameliorates motor symptoms without slowing neurodegeneration in mice with respiratory chain-deficient dopamine neurons
  • Cell Transplant, 2013;22(9):1529-39, doi: 10.3727/096368912X657693. Epub 2012 Oct 8
  • 3) Luo Y, Shen H, Liu HS, Yu SJ, Reiner DJ, Harvey BK, Hoffer BJ, Yang Y, Wang Y.J (2013)
  • CART peptide induces neuroregeneration in stroke rats
  • Cereb Blood Flow Metab, 2013 Feb;33(2):300-10, doi: 10.1038/jcbfm.2012.172. Epub 2012 Dec 5
  • 4) Henderson MJ, Richie CT, Airavaara M, Wang Y, Harvey BK (2013)
  • Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors
  • J Biol Chem, 2013 Feb 8;288(6):4209-25., doi: 10.1074/jbc.M112.400648. Epub 2012 Dec 19
  • 5) Airavaara M, Harvey BK, Voutilainen MH, Shen H, Chou J, Lindholm P, Lindahl M, Tuominen RK, Saarma M, Hoffer B, Wang Y (2012)
  • CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice
  • Cell Transplant, 2012;21(6):1213-23. doi: 10.3727/096368911X600948., Epub 2011 Sep 22
  • 6) Yu SJ, Airavaara M, Shen H, Chou J, Harvey BK, Wang Y (2012)
  • Suppression of endogenous PPARγ increases vulnerability to methamphetamine-induced injury in mouse nigrostriatal dopaminergic pathway
  • Psychopharmacology (Berl), 2012 Jun;221(3):479-92, doi: 10.1007/s00213-011-2595-7. Epub 2011 Dec 13
  • 7) Li Y, Chigurupati S, Holloway HW, Mughal M, Tweedie D, Bruestle DA, Mattson MP, Wang Y, Harvey BK, Ray B, Lahiri DK, Greig NH (2012)
  • Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
  • 8) Wires ES, Alvarez D, Dobrowolski C, Wang Y, Morales M, Karn J, Harvey BK (2012)
  • Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells
  • J Neurovirol, Oct;18(5):400-10, doi: 10.1007/s13365-012-0103-4. Epub 2012 May 22
  • 9) Shen H, Harvey BK, Chiang YH, Pick CG, Wang Y (2011)
  • Methamphetamine potentiates behavioral and electrochemical responses after mild traumatic brain injury in mice
  • Brain Res, 2011 Jan 12, 1368:248-53. doi: 10.1016/j.brainres.2010.10.014.
  • 10) Airavaara M, Pickens CL, Stern AL, Wihbey KA, Harvey BK, Bossert JM, Liu QR, Hoffer BJ, Shaham Y (2011)
  • Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving
  • Addict Biol, 2011 Apr;16(2):261-72, doi: 10.1111/j.1369-1600.2010.00281.x. Epub 2010 D
  • 11) Liu HS, Shen H, Harvey BK, Castillo P, Lu H, Yang Y, Wang Y (2011)
  • Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats
  • Neuroimage, 2011 May 1;56(1):280-9, doi: 10.1016/j.neuroimage.2011.02.049. Epub 2011 F
  • 12) Guez-Barber D, Fanous S, Golden SA, Schrama R, Koya E, Stern AL, Bossert JM, Harvey BK, Picciotto MR, Hope BT (2011)
  • FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons
  • J Neurosci, 2011 Mar 16;31(11):4251-9, doi: 10.1523/JNEUROSCI.6195-10.2011
  • 13) Deng P, Pang ZP, Lei Z, Shikano S, Xiong Q, Harvey BK, London B, Wang Y, Li M, Xu ZC (2011)
  • Up-regulation of A-type potassium currents protects neurons against cerebral ischemia
  • J Cereb Blood Flow Metab, 2011 Sep;31(9):1823-35, doi: 10.1038/jcbfm.2011.88. Epub 2011 Jun 15
  • 14) Harvey BK, Airavaara M, Hinzman J, Wires EM, Chiocco MJ, Howard DB, Shen H, Gerhardt G, Hoffer BJ, Wang Y (2011)
  • Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of stroke
  • PLoS One, 2011;6(8):e22135. doi: 10.1371/journal.pone.002213, Epub 2011 Aug 10
  • 15) Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, Talmadge R, Harvey BK, Wyatt RM, Vernon-Pitts E, Zhang C, Shokat K, Fraser-Liggett C, Balice-Gordon RJ, Tessarollo L, Ward CW (2011)
  • Genetic deletion of trkB.T1 increases neuromuscular function
  • Am J Physiol Cell Physiol, 2012 Jan 1;302(1):C141-53. , doi: 10.1152/ajpcell.00469.2010. Epub 2011 Oct 5
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