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Senior Investigator

Barry Horwitz, Ph.D.

Voice, Speech and Language Branch, NIDCD
Building 10 Room 8S235
10 Center Drive MSC 1402
Bethesda MD 20892-1402
Office: (301) 594-7755

Fax: (301) 480-5625

Dr. Horwitz received his B.A. degree from Washington University in St. Louis and his Ph.D. in physics from the University of Pennsylvania. After several years of teaching physics, he joined the NIA as a Senior Staff Fellow in the Laboratory of Neurosciences, headed by Stanley I. Rapoport. Dr. Horwitz's work focused on developing methods for using positron emission tomography to determine how different brain regions interact in human subjects. In 1989, he obtained tenure and in 1999 he joined the Language Section, NIDCD, as a Senior Investigator. In 2002, he became Chief of the Brain Imaging and Modeling Section of NIDCD. Dr. Horwitz's laboratory currently studies the neural basis of human cognition, especially auditory and language function, using functional brain imaging and computational neural modeling.

Current research focuses on understanding how the brain constructs networks of interacting regions (i.e., neural networks) to perform cognitive tasks, especially those associated with audition and language, and how these networks are altered in brain disorders. These issues are addressed by combining computational neuroscience techniques with functional neuroimaging data, obtained using fMRI, PET, or MEG. The network analysis methods allow us to evaluate how brain operations differ between tasks and between normal and patient populations. This research will allow us to ascertain which networks are dysfunctional, and the role neural plasticity plays in enabling compensatory behavior to occur. A unique aspect of our research is that most of the experiments we do are linked to our modeling, in that these experiments are performed to either acquire data for developing our models or else for testing them.

Staff Image
  • Yvonne Bennett
    Research Fellow
    (301) 594-7758

  • Fatima Husain, Ph.D.
    Special Volunteer
    (217) 333-7561

  • Jieun Kim
    Visiting Fellow
    (301) 594-7757

  • Ajay Pillai, Ph.D.
    Visiting Fellow
    (301) 594-5141

  • Feng Rong
    Visiting Fellow
    (301) 451-1657

  • Jason Smith
    Postdoctoral Fellow
    (301) 451-1647

  • 1) Horwitz, B., Wise, R.J.S. (2008)
  • PET research of language
  • Handbook of the Neuroscience of Language, 71-80
  • 2) Horwitz, B., Husain, F.T. (2007)
  • Simulation frameworks for large-scale brain systems
  • Handbook of Brain Connectivity, 275-302
  • 3) Lee, L., Friston, K.J., Horwitz, B. (2006)
  • Large-scale neural models and Dynamic Causal Modelling
  • NeuroImage, 30, 1243-1254
  • 4) Horwitz, B., Warner, B., Fitzer, J., Tagamets, M.-A., Husain, F.T., Long, T.W. (2005)
  • Investigating the neural basis for functional and effective connectivity: Application to fMRI
  • Phil. Trans. Roy. Soc. Lond. B, 306, 1093-1108
  • 5) Husain, F.T., Lozito, T., Ulloa, A., Horwitz, B. (2005)
  • Investigating the neural basis of the auditory continuity illusion,
  • J. Cogn. Neurosci., 17, 1275-1292
  • 6) Husain FT, Tagamets MA, Fromm SJ, Braun AR, Horwitz B. (2004)
  • Relating neuronal dynamics for auditory object processing to neuroimaging activity: a computational modeling and an fMRI study.
  • Neuroimage, 21(4), 1701–20
  • 7) Glabus MF, Horwitz B, Holt JL, Kohn PD, Gerton BK, Callicott JH, Meyer-Lindenberg A, Berman KF. (2003)
  • Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory.
  • Cerebral Cortex, 13(12), 1352–61
  • 8) Husain, F.T., Nandipati, G., Braun, A.R., Cohen, L.G., Tagamets, M.-A. and Horwitz, B (2002)
  • Simulating transcranial magnetic stimulation during PET with a large-scale neural network model of the prefrontal cortex and the visual system
  • NeuroImage, 15, 58-73
  • 9) Bokde, A.L.W., Tagamets, M.-A., Friedman, R.B. and Horwitz, B (2001)
  • Functional interactions of the inferior frontal cortex during the processing of words and word-like stimuli
  • Neuron, 30, 609-617
  • 10) Horwitz, B., Friston, K.J. and Taylor, J.G (2000)
  • Neural modeling and functional brain imaging: An overview
  • Neural Networks, 13, 829-846
  • 11) Horwitz, B., Tagamets, M.-A. and McIntosh, A.R (1999)
  • Neural modeling, functional brain imaging and cognition
  • Trends in Cognitive Sciences, 3, 91-98
  • 12) Tagamets, M.-A., Horwitz, B. (1998)
  • Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging study
  • Cerebral Cortex, 8, 310-320
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