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Senior Investigator

Armin Raznahan, M.D., Ph.D.

Developmental Neurogenomics Unit (DNU)

Building 10 Room 4D-18
10 Center Drive
Bethesda MD 20892
Office: (301) 435-7927

Armin Raznahan, MD, PhD, is a Lasker Clinical Research Scholar and Chief of the Developmental Neurogenomics Unit. His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Clinically, Dr. Raznahan works as a Child Psychiatrist within the NIH Clinical Center Psychiatry Consultation Liaison Service. He has a degree in Medicine and a PhD in Biological Psychiatry from King's College University London, UK. He has completed residencies in pediatrics and psychiatry, and a specialist fellowship in child and adolescent psychiatry at the Maudsley Hospital, London, UK.

The Developmental Neurogenomics Unit (DNU) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection and treatment. Together with our collaborators, we work towards this goal in two mutually-informative ways.

First, we use large-scale longitudinal neuroimaging datasets to study the architecture of brain development in healthy volunteers. By modeling how neuroimaging measures of the human brain vary with age, sex and behavior in health, we hope to advance basic developmental neuroscience while also providing a data-driven way of selecting neuroimaging measures that should be prioritized for study in atypically developing groups.

Second, we use a "genetics-first" strategy to study the relationship between atypical brain development and neuropsychiatric symptoms. This effort involves gathering "deep-phenotypic" data (spanning measures of gene expression, brain structure/function, psychophysiology, cognition and behavior) in diverse genetic disorders which all increase risk for neuropsychiatric impairment. Guided by knowledge of typical development, we harness these clinical data to empirically dissect the diverse biological pathways that can contribute to the emergence of neuropsychiatric syndromes.

Cross-cutting themes of special interest within our Unit include sex-differences, allometry, and structure-function relationships within the central nervous system.

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  • 1) Raznahan A, Shaw PW, Lerch JP, Clasen LS, Greenstein D, Berman R, Pipitone J, Chakravarty MM, Giedd JN. (2014)
  • Longitudinal four-dimensional mapping of subcortical anatomy in human development
  • Proc Natl Acad Sci USA, 111:1592–1597, PMID: 24474784.
  • 2) Raznahan A, Lee NR, Greenstein D, Wallace GL, Blumenthal JD, Clasen LS, Giedd JN. (2014)
  • Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development
  • Cereb Cortex, PMID: 25146371.
  • 3) Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R. (2014)
  • Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies
  • Brain Struct Funct., PMID: 25146308.
  • 4) Raznahan A, Wallace GL, Antezana L, Greenstein D, Lenroot R, Thurm A, Gozzi M, Spence S, Martin A, Swedo SE, Giedd JN. (2013)
  • Compared to what? Early brain overgrowth in autism and the perils of population norms
  • Biol Psychiatry, 74:563–575 , PMID: 23706681.
  • 5) Raznahan A, Greenstein D, Lee NR, Clasen LS, Giedd JN. (2012)
  • Prenatal growth in humans and postnatal brain maturation into late adolescence
  • Proc Natl Acad Sci U S A. , 109:11366–11371, PMID: 22689983.
  • 6) Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN. (2011)
  • How does your cortex grow?
  • J Neurosci., 31:7174–7177, PMID: 21562281.
  • 7) Raznahan A, Lerch JP, Lee N, Greenstein D, Wallace GL, Stockman M, Clasen L, Shaw PW, Giedd JN. (2011)
  • Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling
  • Neuron, 72:873–884, PMID: 22153381.
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