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Ted B. Usdin, M.D., Ph.D., Senior Investigator

Dr. Usdin received his B.A. degree from Johns Hopkins University. He received M.D. and Ph.D. degrees from the Medical Scientist Training Program at Washington University in St. Louis. His graduate work with Gerald Fischbach focused on the identification of factors responsible for neuromuscular junction development. Dr. Usdin completed a residency in psychiatry at Stanford University and then in 1990 joined the Laboratory of Cell Biology in NIMH. In 1997 he became an Investigator in the Laboratory of Genetics in NIMH. Dr. Usdin's laboratory is exploring the biological role of tuberoinfundibular peptide, a new neuropeptide that his group recently discovered.
Photo of Ted B. Usdin, M.D., Ph.D., Senior Investigator

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Localization of TIP39 and the PTH2 receptor(click for explanation)

Localization of TIP39 and the PTH2 receptor.

Neurotransmitters and neuromodulators, together with their receptors and transporters, are molecules responsible for communication between neurons. These molecules provide accessible sites for studying modulation of neuronal circuits, and are the targets for many drugs. Our work over the last several years lead to the discovery and identification of several neurotransmitter transporters and receptors, and characterization of their genes. Projects in my laboratory are aimed at opening new areas for exploration of neurobiological function, understanding the biological functions of newly discovered genes, and asking whether they contribute to disease pathology or whether they are potential sites for therapeutic intervention.

A recent project in the laboratory started with our discovery of a receptor that we named the parathyroid hormone 2 (PTH2) receptor. This receptor is activated by parathyroid hormone, but its anatomical distribution and functional differences between the receptor isolated from several species lead us to look for an another endogenous peptide that might be its physiological ligand. We recently purified a previously unknown polypeptide, TIP39, from the hypothalamus based on selective activation of the PTH2 receptor. A number of projects in the laboratory are now aimed at elucidating the physiological role of this new peptide-receptor system. These include testing specific hypotheses for its function that are derived from our mapping of their anatomical distributions. Testing TIP39 and the PTH2 receptor as modulators of pain perception and pituitary hormone secretion are ongoing projects. We use a wide range of approaches and techniques including molecular cloning, protein purification, functional neuroanatomy, molecular pharmacology, whole animal behavior and pharmacology, generation of transgenic mice, and cDNA microarrays.


Contact Information:

Dr. Ted B. Usdin
Laboratory of Genetics, NIMH
Porter Neuroscience Research Center
Building 35. Room 1B-215
35 Covent Drive, MSC 3728
Bethesda, MD 20892-3728

Telephone: (301) 402-6976 (office), (301) 435-5465 (fax)
Email: usdin@codon.nih.gov

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