Synaptic Function Section - Publications

• Qian Cai, Hesham Mostafa Zakaria, Anthony Simone, and Zu-Hang Sheng (2012) Spatial Parkin Translocation and Degradation of Depolarized Mitochondria via Mitophagy in Live Cortical Neurons, Current Biology 22, 545-552. Full Text/Abstract

• Zu-Hang Sheng & Qian Cai (2012) Mitochondrial Transport in Neurons: Impact on Synaptic Homeostasis and Neurodegeneration (Review article), Nature Reviews Neuroscience 13, 77-93. Full Text/Abstract

• Bing Zhou, Qian Cai, Yuxiang Xie, and Zu-Hang Sheng (2012) Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons, Cell Reports 2, 42-51. Full Text/Abstract

• Qian Cai and Zu-Hang Sheng (2011) Uncovering the role of Snapin in regulating autophagy-lysosomal function, Autophagy 7, 445-447. Full Text/Abstract

• Yi-Bing Zhu, Zu-Hang Sheng (2011) Increased Axonal Mitochondrial Mobility Does Not Slow ALS-like Disease in Mutant SOD1 Mice, The Journal of Biological Chemistry 286, 23432-23440. Full Text/Abstract

• Bing Zhou, Yi-Bing Zhu, Lin Lin, Qian Cai, and Zu-Hang Sheng (2011) Snapin deficiency is associated with developmental defects of the central nervous system , Bioscience Reports 31, 151-158. Full Text/Abstract

• Qian Cai, Li Lu, Jin-Hua Tian, Yi-Bing Zhu, Haifa Qiao, and Zu-Hang Sheng (2010) Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons, Neuron 68, 73-86, (Also see Preview by M. Yuzaki). Full Text/Abstract

• Qian Cai and Zu-Hang Sheng (2009) Molecular Motors and Synaptic Assembly., The Neuroscientists 15, 78-89. Full Text/Abstract

• Yan-Min Chen, Claudia Gerwin, and Zu-Hang Sheng (2009) Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons, Journal of Neuroscience 29, 9429-9438. Full Text/Abstract

• Huan Ma, Qian Cai, Wenbo Lu, Zu-Hang Sheng (co-corresponding author), Sumiko Mochida (2009) KIF5B Motor Adaptor Syntabulin Maintains Synaptic Transmission in Sympathetic Neurons, Journal of Neuroscience 29, 13019-13029. Full Text/Abstract

• Qian Cai and Zu-Hang Sheng (2009) Moving or Stopping Mitochondria: Miro as a Traffic Cop by Sensing Calcium (Previews), Neuron 61, 493-496. Full Text/Abstract

• Ping-Yue Pan, Jin-Hua Tian, Zu-Hang Sheng (2009) Snapin facilitates the synchronization of synaptic vesicle fusion, Neuron 61, 412-424. Full Text/Abstract

• Qian Cai and Zu-Hang Sheng (2009) Mitochondrial Transport and Docking in Axons, Experimental Neurology 218, 257-267.

• AG Miriam Leenders, Lin Lin, Li-Dong Huang, Claudia Gerwin, Pei-Hua Lu, and Zu-Hang Sheng (2008) The Role of MAP1A Light Chain 2 in Synaptic Surface Retention of Cav2.2 Channels in Hippocampal Neurons, Journal of Neuroscience 28, 11333-11346. Full Text/Abstract

• Wenbo Lu, Huan Ma, Zu-Hang Sheng, and Sumiko Mochida. (2008) Dynamin and activity regulate synaptic vesicle recycling in sympathetic neurons., The Journal of Biological Chemistry 284, 1930-1937.

• Jian-Sheng Kang, Jin-Hua Tian*, Ping-Yue Pan*, Philip Zald, Cuiling Li, Chuxia Deng, and Zu-Hang Sheng (2008) Docking of Axonal Mitochondria by Syntaphilin Controls their Mobility and Affects Short-term Facilitation (*equal contribution), Cell 132, 137-248. Full Text/Abstract

• Qain Cai, Ping-Yue Pan, and Zu-Hang Sheng (2007) Syntabulin-kinesin-1 family 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly, Journal of Neuroscience 27, 7284-7296 (With Weekly Editorial News). Full Text/Abstract

• Ping-Yue Pan, Qian Cai, Lin Lin, Pei-Hua Lu, Shu-Min Duan, and Zu-Hang Sheng. (2005) SNAP29-mediated modulation of synaptic transmission in cultured hippocampal neurons, The Journal of Biological Chemistry 280, 25769-25779. Full Text/Abstract

• Qian Cai, Claudia Gerwin, and Zu-Hang Sheng (2005) Syntabulin-mediated anterograde transport of mitochondria along the neuronal processes, Journal of Cell Biology 170, 959-969. Full Text/Abstract

• Jin-Hua Tian, Zheng-Xing Wu, Michael Unzicker, Li Lu, Qian Cai, Cuiling Li, Claudia Schirra, Ulf Matti, David Stevens, Chuxia Deng, Jens Rettig, and Zu-Hang Sheng (2005) The Role of Snapin in Neurosecretion: Snapin Knockout Mice Exhibit Impaired Calcium-dependent Exocytosis of Large Dense-core Vesicles in Chromaffin Cells, Journal of Neuroscience 25, 10546-10555 (With Weekly Editorial News). Full Text/Abstract

• Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle & Zhuan Zhou (2005) Activation of GPCRs modulates quantal size in chromaffin cells through Gbg, Nature Neuroscience 8, 1160-1168.

• Wu LJ, Leenders AG, Cooperman S, Meyron-Holtz E, Smith S, Land W, Tsai RY, Berger UV, Sheng ZH, Rouault TA (2004) Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier, Brain Res. 1001, 108-17.

• Pratima Thakur, David R. Stevens, Zu-Hang Sheng and Jens Rettig (2004) Effects of PKA-mediated phosphorylation of Snapin on synaptic transmission in cultured hippocampal neurons, Journal of Neuroscience 24, 6476-6481.

• Judit Boczan, A. G. Miriam Leenders, and Zu-Hang Sheng (2004) Phosphorylation of syntaphilin by PKA modulates its interaction with syntaxin-1 and annuls its inhibitory effect on vesicle exocytosis, The Journal of Biological Chemistry 279, 18911-18919.

• Brij B. Singh, Timothy P. Lockwich, Bidhan C. Bandyopadhyay, Xibao Liu, Sunitha Bollimuntha, So-ching Brazer, Christian Combs, Sunit Das, A.G. Miriam Leenders, Zu-Hang Sheng, Mark A. Knepper, Suresh V. Ambudkar, and Indu S. Ambudkar (2004) VAMP2-Dependent Exocytosis Regulates Plasma Membrane Insertion of TRPC3 Channels and Contributes to Agonist-Stimulated Ca2+ Influx, Molecular Cell 15, 635-646.

• Qian Cai*, Qingning Su*, Claudia Gerwin, Carolyn L. Smith, Zu-Hang Sheng (2004) Syntabulin: a microtubule-associated protein implicated in syntaxin trafficking in neurons , Nature Cell Biology 6, 941-953 (with news & views)(*equal contributions). Full Text/Abstract

• Jin-Hua Tian, Sunit Das, and Zu-Hang Sheng (2003) Ca-dependent phosphorylation of syntaxin-1A by DAP-kinase regulates its interaction with Munc-18, The Journal of Biological Chemistry 278, 26265-26274.

• Sunit Das, Claudia Gerwin, and Zu-Hang Sheng (2003) Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis, The Journal of Biological Chemistry 278, 41221-41226.

• Haitao Song, Liping Nie, Adrian Rodriguez-Contreras, Zu-Hang Sheng, and Ebenexer Yamoah (2003) Functional interaction of auxiliary subunits and synaptic proteins with Ca1.3 may impart hair cell Ca current properties, J Neurophysiol. 89, 1143.

• Sunit Das, Judit Boczan, Claudia Gerwin, Philip B. Zald and Zu-Hang Sheng (2003) Regional and developmental regulation of syntaphilin expression in the brain: a candidate molecular element of synaptic functional differentiation, Molecular Brain Research 116, 38-49.

• Miriam Leenders, Arn M. J. M. van den Maagdenberg, Fernando H. Lopes da Silva, Zu-Hang Sheng, Peter C. Molenaar and Wim E.J.M. Ghijsen (2002) Neurotransmitter release from tottering mice nerve terminals with reduced expression of mutated P-, Q-type Ca2+-channels, Eur. J. Neuroscience 15, 13-18.

• Milan G. Chheda, Uri Ashery, Pratima Thakur, Jens Rettig,and Zu-Hang Sheng (2001) PKA phosphorylation of Snapin: modulating its interaction with the SNARE complex, Nature Cell Biology 3, 331-338.

• Qingning Su, Sumiko Mochida, Jin-Hua Tian, Rashi Mehta,and Zu-Hang Sheng (2001) SNAP-29: A General SNARE Protein that Inhibits SNARE Disassembly and is Implicated in Synaptic Transmission, Proc. Natl. Acad. Sci. USA 98, 1438-1443.

• Guifang Lao, Volker Scheuss, Claudia M. Gerwin, Qingning Su, Sumiko Mochida, Jens Rettig, and Zu-Hang Sheng. (2000) Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly, Neuron 25, 191-201.

• Lucas D. Pozzo-Miller, Wolfram Gottschalk, Li Zhang, Kathryn McDermott, Chikara Oho, Zu-Hang Sheng, and Bai Lu (1999) The role of BDNF in Hippocampal synaptic plasticity: impairment in synaptic vesicle docking and synaptic protein distribution in BDNF knockout mice, J. Neuroscience 19, 4972-4983.

• Jeffrey M. Ilardi, Sumiko Mochida, and Zu-Hang Sheng (1999) Snapin: a SNARE-associated protein implicated in synaptic transmission, Nature Neuroscience 2, 119-124.

• Zu-Hang Sheng, Ruth E. Westenbroek, and William A. Catterall (1998) Physical link and functional coupling of presynaptic calcium channels and synaptic vesicle docking/fusion machinery, J. Bioenergetics & Biomembranes 30, 335-345.

• Zu-Hang Sheng, Charles Yokoyoma, and William A. Catterall (1997) Interaction of the synprint site of N-type calcium channels with the C2B domain of synaptotagmin I, Proc. Natl. Acad. Sci. USA 94, 5405-5410.

• Jens Rettig, Christian Heinemann, Uri Ashery, Zu-Hang Sheng, Charles T. Yokoyama, William A. Catterall, and Erwin Neher (1997) Alteration of Ca2+ dependence of neurotransmitter release by disruption of Ca2+ channel/SNARE protein interaction, J Neuroscience 17, 6647-6656.

• Charles Yokoyama, Zu-Hang Sheng, and William A. Catterall (1997) Phosphorylation of the synprint site on N-type calcium channels inhibits interactions with SNARE protein, J Neuroscience 17, 6929-6938.

• Sumiko Mochida, Zu-Hang Sheng, Carl Baker, Haruo Kobayashi, and William A. Catterall (1996) Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type calcium channels, Neuron 17, 781-788.

• Jens Rettig, Zu-Hang Sheng, D. Kyle Kim, Connie D. Hodson, Terry P. Snutch, and William A. Catterall (1996) Isoform-specific interaction of the a1A subunits of brain calcium channels with the presynaptic proteins syntaxin and SNAP-25, Proc. Natl. Acad. Sci. USA 93, 7363-7368.

• Zu-Hang Sheng, Jens Rettig, Terry Cook, and William A. Catterall (1996) Calcium dependent interaction of neuronal N-type calcium channels with presynaptic fusion proteins, Nature 379, 451-454.

• Zu-Hang Sheng, Jens Rettig, Masami Takahashi, and William A. Catterall (1994) Identification of a syntaxin-binding site on N-type calcium channels, Neuron 13, 1303-1313.

• Zu-Hang Sheng, Hui Zhang, Robert L. Barchi, and Roland G. Kallen (1994) Molecular cloning and functional analysis of the promoter of rat skeletal muscle voltage-sensitive sodium channel subtype 2 (rSkM2): evidence for muscle-specific nuclear protein binding to the core promoter, DNA and Cell Biology 13, 9-23.

• Roland G. Kallen, Zu-Hang Sheng, Liquiong Chen, Jan Yang, Rogart, R.B., and Robert L. Barchi (1990) Primary structure and differential expression of a sodium channel characteristic of immature and denervated rat skeletal muscle, Neuron 4, 233-242.

• Trimmer, J.S., Cooperman, S.S., Tomiko, S.A., Zhou, J., Crean, S.M., Boyle, M.B., Kallen, R.G., Zu-Hang Sheng, Barchi, R.L., Sigworth, F.J., Goodman, R.G., Agnew, S.A., and Mandel, G (1989) Primary structure and functional expression of a mammalian skeletal muscle sodium channel, Neuron 3, 33-49.