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Francis J. McMahon, M.D., Investigator

Dr. McMahon received his B.A. in Biology from the University of Pennsylvania in 1982 and his M.D. from Johns Hopkins University School of Medicine in 1987. He stayed on at Hopkins to complete a medical internship, a residency in adult psychiatry, and a post-doctoral fellowship in psychiatric genetics before joining the faculty in 1993. In 1998, he became Associate Professor of Psychiatry and medical director of the Electroconvulsive Therapy Clinic at the University of Chicago. In 2002, he joined the Mood and Anxiety Disorders Program as chief of its Genetics Unit. Recently, Dr. McMahon was named a Mallinckrodt Scholar by the Edward F. Mallinckrodt Foundation. He also serves as a scientific advisor for the National Tourette Syndrome Association, the University of Antwerp, the RIKEN Brain Science Institute, and numerous scientific journals. Current research priorities include fine-mapping bipolar disorder susceptibility loci on chromosomes 6q, 13q, 18q, and 22q; identification of clinical features that define highly familial clinical subtypes of mood disorders; and the elucidation of parent-of-origin effects in the familial transmission of mood disorders.
Photo of Francis J. McMahon, M.D., Investigator

Staff:
Staff Photo for Genetic Basis of Mood and Anxiety Disorders Unit


Research Interests:
Our mission is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed.

We are recruiting families with multiple cases of mood disorder for use in genetic mapping studies. Volunteers are asked to provide a blood sample and undergo a psychiatric interview, usually over the telephone.

Current research priorities include genome-wide linkage mapping of bipolar susceptibility genes, fine-mapping bipolar disorder susceptibility loci on chromosomes 6q, 13q, 18q, and 22q; identification of clinical features that define highly familial clinical subtypes of mood disorders; the elucidation of parent-of-origin effects in the familial transmission of mood disorders; and candidate gene studies of the serotonin transporter, glucocorticoid receptor, and nuclear receptor genes. We also study patterns of linkage disequilibrium and "haplotype blocks" in the human genome.


Clinical Protocols:
  • Bipolar Disorder Genetics: A Collaborative Study ( 80-M-0083 )

Contact Information:

Dr. Francis J. McMahon
Genetic Basis of Mood and Anxiety Disorders Unit, NIMH
Porter Neuroscience Research Center
Building 35, Room 1A-202
35 Convent Dr, MSC 3719
Bethesda, MD 20892-3719

Telephone: (301) 451-4455 (office), (301) 451-4453 (laboratory), (301) 402-7094 (fax)
Email: mcmahonf@intra.nimh.nih.gov

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