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Daniel Samuel Pine, M.D., Senior Investigator

Dr. Pine received his B.A. in anthropology from Grinnell College in 1985 and his M.D. from the University of Chicago Pritzker School of Medicine in 1990. He completed an internship in pediatrics, a residency in general psychiatry, and fellowships in both child psychiatry and child psychiatry research at the College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute. Dr. Pine held both junior and senior faculty positions at Columbia, where he studied epidemiology, psychobiology, and therapeutics of childhood mood and anxiety disorders, working with David Shaffer, Patricia Cohen, as well as Donald and Rachel Klein. In 2000, he moved to the Mood and Anxiety Disorders Program within the NIMH as Chief of the Section on Development and Affective Neuroscience. Dr. Pine received a NARSAD Independent Investigator Award, a NIMH Career Development Award and the Blanche Ittelson Award from the American Psychiatric Association. His laboratory investigates the neural and psychological correlates of pediatric mood and anxiety disorders.
Photo of Daniel  Samuel Pine, M.D., Senior Investigator


Research Interests:
The Section on Development and Affective Neuroscience examines the relationships among brain development, emotion regulation, and risk for mood and anxiety disorders in children and adolescents. The broad goal of research conducted within the section is to define the manner in which developmental changes in brain function relate to normal changes in emotion regulation during development and to mood or anxiety disorders manifest in children and adolescents. To accomplish this goal, the section emphasizes application of fMRI to questions on emotional development, performing fMRI studies using various traditional paradigms from cognitive and affective neuroscience. However, fMRI provides only one tool used to define the manner in which changes in brain systems relate to development and to manifestations of mood and anxiety disroders across the lifespan. Other projects will use behavioral measures of emotion regulation, genetically-informative research designs, and treatment strategies. This will include studies examining changes in brain structure and function during treatment for a mood or anxiety disorder. Overall, the planned studies will answer questions in children and adolescents on neural correlates of developmental changes in emotional regulation, risk or symptom patterns in mood and anxiety disorders, as well as the effects of treatments for mood and anxiety disorders on the developing brain.

Clinical Protocols:
  • Fluoxetine’s effects on vigilance and emotional memory in anxious and depressed youth  ( 01-M-0192 )
  • Adolescence, Puberty, and Emotion Regulation: An fMRI Study  ( 01-M-0152 )

Selected Recent Publications:
  • Lau JYF, Britton JC, Nelson EE, Angold A, Ernst M, Goldwin M, Grillon C, Leibenluft E, Lissek S, Norcross M, Shiffrin N, Pine DS (InPress) Distinct neural signatures of threat learning in adolescents and adults, Proc Natl Acad Sci USA.

  • Blair K, Geraci M, Korelitz K, Otero M, Towbin K, Ernst M, Leibenluft E, Blair RJR, Pine DS (InPress) The pathology of social phobia is independent of developmental changes in face processing, Am J Psychiatry .

  • Guyer AE, Choate VR, Detloff A, Benson B, Nelson EE, Perez-Edgar K, Fox NA, Pine DS (InPress) Ernst M: Striatal functional alterations during incentive anticipation in pediatric anxiety disorders, Am J Psychiatry .

  • Pine DS, Helfinstein SM, Bar-Haim Y, Nelson E, Fox NA (2009) Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety, Neuropsychopharmacology 34, 213-28.

  • Beesdo K, Lau J, McClure-Tone EB, Guyer AE, Monk CS, Neslon EE, Fromm SJ, Goldwin MA, Wittchen H-U, Leibenluft E, Ernst M, Pine DS (2009) Common and specific amygdala-function perturbations in depressed versus anxious adolescents, Arch Gen Psychiatry 66, 275-85.

  • Guyer AE, Lau JYF, McClure-Tone EB, Parrish J, Shiffrin ND, Reynolds RC, Chen G, Blair RJR, Leibenluft E, Fox NA, Ernst M, Pine DS, Nelson EE (2008) Amygdala and vlPFC function during anticipated peer evaluation in pediatric social anxiety, Arch Gen Psychiatry 65, 1303-12.

  • Blair K, Geraci M, Devido J, McCaffrey D, Chen G, Vythilingam M, Ng P, Hollon N, Jones M, Blair RJR, Pine DS (2008) The neural response to self-and- other-referential praise and criticism in generalized social phobia, Arch Gen Psychiatry 65, 1176-84.

All Selected Publications

Contact Information:

Dr. Daniel Samuel Pine
Development and Affective Neuroscience Section
National Institute of Mental Health
Building 1, Room B310-0135
1 Center Drive MSC 0135
Bethesda, MD 20895-0135

Telephone: (301) 594-1318 (office),


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