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Leslie G. Ungerleider, Ph.D., Senior Investigator

Dr. Ungerleider received her B.A. degree from the State University of New York at Binghamton and her Ph.D. degree, with a major in Experimental Psychology, from New York University. During her postdoctoral training with Karl Pribram at Stanford University, she began her work on higher-order perceptual mechanisms in the cortex of primates. She moved to the NIMH in 1975, joining Mortimer Mishkin in the Laboratory of Neuropsychology. Their neurobehavioral work inspired their theory of 'two cortical visual systems', one specialized for object recognition and another for visuospatial perception. In 1995, Dr. Ungerleider became Chief of the Laboratory of Brain and Cognition at NIMH. She is a member of the National Academy of Sciences, the Institute of Medicine of the National Academy of Sciences, and the American Academy of Arts and Sciences. In 2001, she was the recipient of the Women in Neuroscience Lifetime Achievement Award and in 2008 she became an NIH Distinguished Investigator.
Photo of Leslie  G. Ungerleider, Ph.D., Senior Investigator

Staff:



Research Interests:
Dr. Ungerleider's Section has long been devoted to establishing the links between neural structure and cognitive function, especially in the visual modality. Most of her early work focused on anatomical tracing techniques in macaque monkeys in order to delineate the areas that comprise visual association cortex and their interconnections. By the mid-1990s, she and others had succeeded in mapping much of the monkey extrastriate visual cortex and had outlined some of the major functional systems. With the basic anatomical data in hand, she then addressed more functional questions, including: 1) behavioral assessment of selective brain lesions in the cortical areas she had previously mapped; and 2) physiological recordings of neural activity in awake, behaving monkeys. With the advent of functional brain imaging in humans, she also began brain imaging studies of human cortex, using first PET and then fMRI. The monkey work has guided many of her hypotheses in the human imaging studies, and findings from the imaging studies have provided a broader, systems-level picture than could have been derived from the monkey work alone. Dr. Ungerleider has recently expanded her monkey program to include monkey fMRI in order to expand upon the parallel studies in humans and monkeys for which her lab is recognized.

Her work on visual attention has shown that in a typical scene many different objects compete for neural representation due to the limited processing capacity of the visual system. The competition among multiple objects can be biased by both bottom-up sensory-driven mechanisms and top-down influences, such as selective attention. Although the competition among stimuli is ultimately resolved within visual cortex, the source of top-down biasing signals derives from a distributed network of frontal and parietal areas. This biased competition model of attention suggests that once attentional resources are depleted, no further processing is possible. Dr. Ungerleider's more recent work has shown that, similar to the processing of other stimulus categories, the processing of stimuli with emotional valence is under top-down control, requiring attentional resources.


Clinical Protocols:
  • Comparing fMRI and Neuronal Activity in the Awake Behaving Monkey ( ASP LN-22 )
  • Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory ( 93-M-0170 )

Selected Recent Publications:
  • Ungerleider, L.G., Galkin, T.W., Desimone, R., and Gattass, R. (2008) Cortical connections of area V4 in the macaque. , Cerebral Cortex 18, 477-499.

  • Hadj-Bouziane, F., Bell, A.H., Knusten, T.A., Ungerleider, L.G., and Tootell, R.B.H. (2008) Perception of emotional expression activates regions independent of face selectivity in monkey inferior temporal cortex: a fMRI study. , Proc. Natl. Acad. Sci. USA 105, 5591-5596.

  • Tootell, R.B.H., Devaney, K.J., Young, J.C., Postelnicu, G., Rajimehr, R., and Ungerleider, L.G. (2008) fMRI mapping of a morphed continuum of 3D shapes within inferiortemporal cortex., Proc. Natl. Acad. Sci. USA 105, 3605-3609.

  • Mukai, I., Kim, D., Fukunaga, M., Japee, S., Marrett, S., and Ungerleider, L.G. (2007) Activations in visual and attention-related areas predict and correlate with the degree of perceptual learning. , J. Neurosci. 27, 11401-11411.

  • Rossi, A.F., Bichot, N.P., Desimone, R., and Ungerleider, L.G. (2007) Top-down attentional deficits in macaques with lesions of lateral prefrontal cortex. , J. Neurosci. 27, 11306-11314.

  • Heekeren, H.R., Marrett, S., Ruff, D.A., Bandettini, P.A., and Ungerleider, L.G. (2006) Involvement of left dorsolateral prefrontal cortex in perceptual decision-making is independent of response modality., Proc. Natl. Acad. Sci. USA 103, 1023-1028.

  • Pessoa, L., Japee, S., Sturman, D.., and Ungerleider, L.G. (2006) Target visibility and visual awareness modulate amygdala responses to fearful faces., Cerebral Cortex 16, 366-375.

All Selected Publications


Contact Information:

Dr. Leslie G. Ungerleider
Neurocircuitry Section
Laboratory of Brain & Cognition, NIMH
Building 10, Room 4C104
10 Center Drive, MSC 1366
Bethesda, MD 20892-1366

Telephone: (301) 435-4932 (office), (301) 402-0921 (fax)
Email: ungerlel@mail.nih.gov

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