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| De-Maw Chuang, Ph.D., Senior Investigator |
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Dr. Chuang received his Ph.D. degree from the State University of New York at Stony Brook. He has been Chief of the Molecular Neurobiology Section of NIMH since 1999. Dr. Chuang's research has centered on the mechanisms and actions of mood-stabilizing drugs as well as the mechanisms of apoptosis and its implications in neuropsychiatric and neurological diseases. His lab has provided the first evidence that the mood-stabilizers lithium and valproate robustly protect CNS neurons from glutamate-induced excitotoxicity in vivo and in vitro, and has identified the initial targets and potential mechanisms underlying this neuroprotection. He has received the NIH Director's Award in 1997, NARSAD Distinguished Investigator Award in 2002, and induction as a member of Academia Sinica in 2006.
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Research Interests:
Mechanisms and actions of mood-stabilizing drugs as well as the mechanisms of apoptosis and its implications in neuropsychiatric and neurological diseases.
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Selected Recent Publications:
Yasuda S, Liang M-H, Marinova Z, Yahyavi A and Chuang D-M (2009) The mood stabilizers lithium and valproate selectively activate promoter IV of brain-derived neurotrophic factor in neurons, Mol Psychiatry 14, 51-59.
Leng Y, Liang M-H, Ren M, Marinova Z, Leeds P and Chuang D-M (2008) Synergistic neuroprotective effects of lithium and valproic acid or other HDAC inhibitors in neurons: Roles of GSK-3 inhibition, J Neurosci 28, 2576-2588.
Liang M-H and Chuang D-M (2007) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival, J Biol Chem 282, 3904-3917.
Liang M-H and Chuang D-M (2006) Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation, J Biol Chem 281, 30479-30484.
Chen P-S, Peng G-S, Li G, Yang S, Wu X, Wang C-C, Wilson B, Lu R-B, Gean P-W, Chuang D-M and Hong J-S (2006) Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes, Mol Psychiatry 11, 1116-1125.
Leng Y and Chuang D-M (2006) Endogenous α-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity, J Neurosci 26, 7502-7512.
Chuang D-M, Hough C and Senatorov VV (2005) Glyceraldehyde-3-phosphate dehydrogenase, apoptosis and neurodegenerative diseases, Ann Rev Pharm Tox 45, 269-290.
All Selected Publications
Contact Information:
Dr. De-Maw Chuang
Molecular Neurobiology Section
National Institute of Mental Health
Building 10, Room 3D38
10 Center Drive MSC 1363
Bethesda, MD 20892-1363
Telephone: (301) 496-4915 (office),
(301) 496-7761 (laboratory),
(301) 480-9290 (fax)
Email: chuang@mail.nih.gov
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